Browsing Regenerative Medicine Institute (Scholarly Articles) by Title
Now showing items 14-33 of 41
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Editorial: Innovative biologics and drugs to target renal inflammation
(Frontiers Media, 2020-02-06)[No abstract available] -
Effect of sodium glucose co-transporter-2 inhibition on the Aldosterone/Renin Ratio in Type 2 Diabetes Mellitus
(Thieme Publishing, 2018-12-06)The aldosterone to renin ratio (ARR) is recommended for case detection of primary aldosteronism (PA). Several factors including medications can undermine its diagnostic accuracy. The objective was to explore the effect of ... -
Effects of growth phase and temperature on sigma(B) Activity within a Listeria monocytogenes population: evidence for RsbV-independent activation of sigma(B) at refrigeration temperatures
(Hindawi Publishing Corporation, 2014-03-05)The alternative sigma factor sigma(B) of Listeria monocytogenes is responsible for regulating the transcription of many of the genes necessary for adaptation to both food-related stresses and to conditions found within the ... -
Effects of mesenchymal stromal cells on regulatory T cells: Current understanding and clinical relevance
(AlphaMed Press and Wiley, 2020-01-29)The immunomodulatory potential of mesenchymal stromal cells (MSCs) and regulatory T cells (T-reg) is well recognized by translational scientists in the field of regenerative medicine and cellular therapies. A wide range ... -
Endothelial nitric oxide synthase induces heat shock protein HSPA6 (HSP70B ) in human arterial smooth muscle cells
(Elsevier, 2015-12-01)Endothelial nitric oxide synthase (eNOS) is the major source of nitric oxide (NO) production in blood vessels. One of the pleitropic functions of eNOS derived NO is to inhibit vascular smooth muscle cell proliferation ... -
Evaluation of cartilage repair by mesenchymal stem cells seeded on a PEOT/PBT scaffold in an osteochondral defect
(Springer Verlag, 2015-01-15)The main objective of this study was to evaluate the effectiveness of a mesenchymal stem cell (MSC)-seeded polyethylene-oxide-terephthalate/polybutylene-terephthalate (PEOT/PBT) scaffold for cartilage tissue repair in an ... -
Evaluation of the early in vivo response of a functionally graded macroporous scaffold in an osteochondral defect in a rabbit model
(Springer Verlag, 2015-10-05)Cartilage tissue engineering is a multifactorial problem requiring a wide range of material property requirements from provision of biological cues to facilitation of mechanical support in load-bearing diarthrodial joints. ... -
Future directions in managing aniridia-associated keratopathy
(Elsevier, 2023-05-04)Congenital aniridia is a panocular disorder that is typically characterized by iris hypoplasia and aniridia-associated keratopathy (AAK). AAK results in the progressive loss of corneal transparency and thereby loss of ... -
Gene therapy in transplantation: Toward clinical trials
(Thompson, 2009)The genetic modification of organs or cells is an attractive approach to protect allogeneic transplants from acute rejection and other complications. The transplant setting offers a unique opportunity to utilise ex vivo ... -
Genetically Modified Mesenchymal Stem
(2010-03)Adult mesenchymal stem cells (MSCs) are non-hematopoietic cells with multi-lineage potential to differentiate into various tissues of mesodermal origin. They can be isolated from bone marrow and other tissues and have the ... -
High-risk corneal transplantation: Recent developments and future possibilities
(Lippincott, Williams & Wilkins, 2019-12)Human corneal transplantation (keratoplasty) is typically considered to have superior short- and long-term outcomes and lower requirement for immunosuppression compared to solid organ transplants because of the inherent ... -
Human mesenchymal stromal cells broadly modulate high glucose-induced inflammatory responses of renal proximal tubular cell monolayers
(BMC, 2019-11-19)Background: Renal proximal tubular epithelial cells (RPTEC) are dysfunctional in diabetic kidney disease (DKD). Mesenchymal stromal cells (MSC) may modulate DKD pathogenesis through anti-inflammatory mediators. This study ... -
Human monocyte subset distinctions and function: Insights from gene expression analysis
(Frontiers Media, 2020-06-04)Monocytes are a highly plastic innate immune cell population that displays significant heterogeneity within the circulation. Distinct patterns of surface marker expression have become accepted as a basis for distinguishing ... -
Immunogenicity of allogeneic mesenchymal stem cells
(2012)Mesenchymal stem cells (MSCs) inhibit proliferation of allogeneic T cells and express low levels of major histocompatibility complex class I (MHCI), MHCII and vascular adhesion molecule-1 (VCAM-1). We investigated whether ... -
In vitro models for assessing therapeutic angiogenesis
(Elsevier, 2016-06-01)Arterial obstruction leading to ischemia causes a reduction of oxygen and nutrient supply to distal tissues. The physiological response to tissue ischemia triggers a cascade of events that results in the development of ... -
Increased weight gain during the long interdialytic period Is associated with minor effects on blood pressure control in clinically stable in-centre haemodialysis patients
(Karger Publishers, 2018-11-09)Background/Aims: Three-day-a-week chronic haemodialysis (cHD) involves 1 long (72 h) and 2 short (48 h) inter-dialytic periods (IDPs), We aimed to determine whether BP control following the long IDP is inferior to the short ... -
Induced pluripotent stem cells in companion animals: how can we move the field forward?
(Frontiers Media, 2023-04-25)Following a one medicine approach, the development of regenerative therapies for human patients leads to innovative treatments for animals, while pre-clinical studies on animals provide knowledge to advance human medicine. ... -
Inefficiency in macromolecular transport of SCS‐based microcapsules affects viability of primary human mesenchymal stem cells but not of immortalized cells
(Wiley, 2015-05-01)Microcapsules made of sodium cellulose sulphate (SCS) and poly-diallyl-dimethyl-ammonium chloride (pDADMAC) have been employed to encapsulate a wide range of established cell lines for several applications. However, little ... -
Mesenchymal stromal cell–based therapies for acute kidney injury: progress in the last decade
(Elsevier, 2020-01-28)A little over 10 years ago, the therapeutic potential of mesenchymal stromal cells (MSCs) for the treatment of acute kidney injury (AKI) was becoming widely recognized. Since then, there has been further intensive study ... -
A novel high-throughput screening platform identifies itaconate derivatives from marine Penicillium antarcticum as inhibitors of mesenchymal stem cell differentiation
(MDPI, 2020-04-05)Worldwide diffused diseases such as osteoarthritis, atherosclerosis or chronic kidney disease are associated with a tissue calcification process which may involve unexpected local stem cell differentiation. Current ...