dc.contributor.author | Aied, Ahmed | |
dc.contributor.author | Glynn, Barry | |
dc.contributor.author | Cao, Hongliang | |
dc.contributor.author | Zheng, Yu | |
dc.contributor.author | Pandit, Abhay | |
dc.contributor.author | Wang, Wenxin | |
dc.date.accessioned | 2012-10-25T09:56:07Z | |
dc.date.available | 2012-10-25T09:56:07Z | |
dc.date.issued | 2012-01 | |
dc.identifier.citation | Aied, A,Glynn, B,Cao, HL,Zheng, Y,Tai, HY,Pandit, A,Wang, WX (2012) 'A Fluorescently Labeled, Hyperbranched Polymer Synthesized from DE-ATRP for the Detection of DNA Hybridization'. Polymer Chemistry, 3 :332-334. | en_US |
dc.identifier.issn | 1759-9962 | |
dc.identifier.uri | http://hdl.handle.net/10379/3010 | |
dc.description | Journal article | en_US |
dc.description.abstract | The early detection of oligonucleotide biomarkers of disease, such as microRNAs, has been established as a fundamental factor in cancer diagnosis. As the levels of these small molecules (microRNAs) in blood have recently been found to be significantly affected in cancer patients, they offer a means of early stage detection of cancer. Towards the goal of creating a novel method of DNA hybridization detection, we report the detection of specific sequences of small oligonucleotides in a model experiment carried out in serum. The results shown here display the versatility of the DE-ATRP method in synthesizing a specific polymer structure capable of changing its physical properties in the presence of double stranded DNA. The polymer was labeled and used to detect single-stranded DNA in serum successfully. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Royal Society of Chemistry | en_US |
dc.relation.ispartof | Polymer Chemistry | en |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Ireland | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/ie/ | |
dc.subject | Conjugated polymers | en_US |
dc.subject | Micro RNAs | en_US |
dc.title | A Fluorescently Labeled, Hyperbranched Polymer Synthesized from DE-ATRP for the Detection of DNA Hybridization | en_US |
dc.type | Article | en_US |
dc.date.updated | 2012-10-24T11:58:41Z | |
dc.identifier.doi | DOI 10.1039/c2py00516f | |
dc.local.publishedsource | http://dx.doi.org/10.1039/c2py00516f | en_US |
dc.description.peer-reviewed | peer-reviewed | |
dc.contributor.funder | |~| | |
dc.internal.rssid | 1332727 | |
dc.local.contact | Abhay Shashikant Pandit, Mechanical & Biomedical Eng, College Of Eng & Informatics, Room 304, Nfb Building, Ida Bus Park, Dangan, Nui Galway. 2758 Email: abhay.pandit@oegaillimh.ie | |
dc.local.copyrightchecked | No | |
dc.local.version | PUBLISHED | |
nui.item.downloads | 570 | |