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dc.contributor.authorAied, Ahmed
dc.contributor.authorGlynn, Barry
dc.contributor.authorCao, Hongliang
dc.contributor.authorZheng, Yu
dc.contributor.authorPandit, Abhay
dc.contributor.authorWang, Wenxin
dc.identifier.citationAied, A,Glynn, B,Cao, HL,Zheng, Y,Tai, HY,Pandit, A,Wang, WX (2012) 'A Fluorescently Labeled, Hyperbranched Polymer Synthesized from DE-ATRP for the Detection of DNA Hybridization'. Polymer Chemistry, 3 :332-334.en_US
dc.descriptionJournal articleen_US
dc.description.abstractThe early detection of oligonucleotide biomarkers of disease, such as microRNAs, has been established as a fundamental factor in cancer diagnosis. As the levels of these small molecules (microRNAs) in blood have recently been found to be significantly affected in cancer patients, they offer a means of early stage detection of cancer. Towards the goal of creating a novel method of DNA hybridization detection, we report the detection of specific sequences of small oligonucleotides in a model experiment carried out in serum. The results shown here display the versatility of the DE-ATRP method in synthesizing a specific polymer structure capable of changing its physical properties in the presence of double stranded DNA. The polymer was labeled and used to detect single-stranded DNA in serum successfully.en_US
dc.publisherRoyal Society of Chemistryen_US
dc.relation.ispartofPolymer Chemistryen
dc.subjectConjugated polymersen_US
dc.subjectMicro RNAsen_US
dc.titleA Fluorescently Labeled, Hyperbranched Polymer Synthesized from DE-ATRP for the Detection of DNA Hybridizationen_US
dc.identifier.doiDOI 10.1039/c2py00516f
dc.local.contactAbhay Shashikant Pandit, Mechanical & Biomedical Eng, College Of Eng & Informatics, Room 304, Nfb Building, Ida Bus Park, Dangan, Nui Galway. 2758 Email:

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