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dc.contributor.authorDaly, William T.
dc.contributor.authorYao, Li
dc.contributor.authorAbu-Rub, Mohammad
dc.contributor.authorZeugolis, Demitrios
dc.date.accessioned2012-10-24T10:42:36Z
dc.date.available2012-10-24T10:42:36Z
dc.date.issued2012-06-25
dc.identifier.citationDaly, WT,Yao, L,Abu-rub, MT,O'Connell, C,Zeugolis, DI,Windebank, AJ,Pandit, AS (2012) 'The effect of intraluminal contact mediated guidance signals on axonal mismatch during peripheral nerve repair'. Biomaterials, 33 :6660-6671.en_US
dc.identifier.issn0142-9612
dc.identifier.urihttp://hdl.handle.net/10379/3006
dc.descriptionJournal articleen_US
dc.description.abstractThe current microsurgical gold standard for repairing long gap nerve injuries is the autograft. Autograft provides a protective environment for repair and a natural internal architecture, which is essential for regeneration. Current clinically approved hollow nerve guidance conduits allow provision of this protective environment; however they fail to provide an essential internal architecture to the regenerating nerve. In the present study both structured and unstructured intraluminal collagen fibres are investigated to assess their ability to enhance conduit mediated nerve repair. This study presents a direct comparison of both structured and unstructured fibres in vivo. The addition of intraluminal guidance structures was shown to significantly decrease axonal dispersion within the conduit and reduced axonal mismatch of distal nerve targets (pen_US
dc.formatapplication/pdfen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofBiomaterialsen
dc.subjectNerve guidance conduiten_US
dc.subjectIn vivoen_US
dc.subjectBiomaterialsen_US
dc.subjectPeripheral nerveen_US
dc.subjectRepairen_US
dc.subjectNerve guideen_US
dc.titleThe effect of intraluminal contact mediated guidance signals on axonal mismatch during peripheral nerve repairen_US
dc.typeArticleen_US
dc.date.updated2012-10-18T16:31:08Z
dc.identifier.doiDOI 10.1016/j.biomaterials.2012.06.002
dc.local.publishedsourcehttp://dx.doi.org/10.1016/j.biomaterials.2012.06.002en_US
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funder|~|
dc.internal.rssid2469046
dc.local.contactAbhay Shashikant Pandit, Mechanical & Biomedical Eng, College Of Eng & Informatics, Room 304, Nfb Building, Ida Bus Park, Dangan, Nui Galway. 2758 Email: abhay.pandit@oegaillimh.ie
dc.local.copyrightcheckedNo
dc.local.versionPUBLISHED
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