Show simple item record

dc.contributor.authorMathew, Asha
dc.contributor.authorCao, Hongliang
dc.contributor.authorCollin, Estelle
dc.contributor.authorWang, Wenxin
dc.contributor.authorPandit, Abhay
dc.identifier.citationMathew, A,Cao, HL,Collin, E,Wang, WX,Pandit, A (2012) 'Hyperbranched PEGmethacrylate linear pDMAEMA block copolymer as an efficient non-viral gene delivery vector'. International Journal Of Pharmaceutics, 434 :99-105.en_US
dc.description.abstractA unique hyperbranched polymeric system with a linear poly-2-dimethylaminoethyl methacrylate (pDMAEMA) block and a hyperbranched polyethylene glycol methyl ether methacrylate (PEGMEMA) and ethylene dimethacrylate (EGDMA) block was designed and synthesized via deactivation enhanced atom transfer radical polymerisation (DE-ATRP) for efficient gene delivery. Using this unique structure, with a linear pDMAEMA block, which efficiently binds to plasmid DNA (pDNA) and hyperbranched polyethylene glycol (PEG) based block as a protective shell, we were able to maintain high transfection levels without sacrificing cellular viability even at high doses. The transfection capability and cytotoxicity of the polymers over a range of pDNA concentration were analysed and the results were compared to commercially available transfection vectors such as polyethylene imine (branched PEI, 25 kDa), partially degraded poly(amido amine) dendrimer (dPAMAM; commercial name: SuperFect (R)) in fibroblasts and adipose tissue derived stem cells (ADSCs). (c) 2012 Elsevier B.V. All rights reserved.en_US
dc.relation.ispartofInternational Journal Of Pharmaceuticsen
dc.subject2-(Dimethylamino) ethyl methacrylateen_US
dc.subjectDeactivation enhanced atom transfer radical polymerisationen_US
dc.subjectGene therapyen_US
dc.titleHyperbranched PEGmethacrylate linear pDMAEMA block copolymer as an efficient non-viral gene delivery vectoren_US
dc.identifier.doiDOI 10.1016/j.ijpharm.2012.05.010
dc.local.contactAbhay Shashikant Pandit, Mechanical & Biomedical Eng, College Of Eng & Informatics, Room 304, Nfb Building, Ida Bus Park, Dangan, Nui Galway. 2758 Email:

Files in this item

Attribution-NonCommercial-NoDerivs 3.0 Ireland
This item is available under the Attribution-NonCommercial-NoDerivs 3.0 Ireland. No item may be reproduced for commercial purposes. Please refer to the publisher's URL where this is made available, or to notes contained in the item itself. Other terms may apply.

The following license files are associated with this item:

This item appears in the following Collection(s)

Show simple item record