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dc.contributor.authorMcCullagh, Karl
dc.date.accessioned2012-07-02T16:11:48Z
dc.date.available2012-07-02T16:11:48Z
dc.date.issued2012
dc.identifier.citationMcCullagh, KJA (2012) 'Can a young muscle s stem cell secretome prolong our lives?'. Stem Cell Research & Therapy, 3 (3).en_US
dc.identifier.urihttp://hdl.handle.net/10379/2895
dc.description.abstractAgeing is a biological certainty for all living organisms, and is due to the loss of tissue homeostasis and regenerative capacity (except for newts) in which somatic stem cells are thought to play an important role. Many ageing-associated dysfunctions in stem cells have been described, but it remains ambiguous whether these are merely an outcome of ageing or are causal. Parabiotic animal studies suggest there are factors in the systemic environment that can infl uence the regenerative capacity of tissues. These factors can be altered by ageing, but it is not clear where these age-dependent factors are derived. A recent provocative study on muscle stem cells, in a mouse model of human progeria, proposes a mechanism that might provide answers to these fundamental ageing questions.en_US
dc.formatapplication/pdfen_US
dc.language.isoenen_US
dc.relation.ispartofStem Cell Research & Therapyen
dc.subjectProgeriaen_US
dc.subjectAgeingen_US
dc.titleCan a young muscle s stem cell secretome prolong our lives?en_US
dc.typeArticleen_US
dc.date.updated2012-07-02T15:51:06Z
dc.local.publishedsourcehttp://stemcellres.com/content/3/3/19en_US
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funder|~|Health Research Board|~|
dc.internal.rssid1901166
dc.local.contactKarl Mccullagh, Dept Of Physiology, Quadrangle Building, Nui Galway. 4220 Email: karl.mccullagh@nuigalway.ie
dc.local.copyrightcheckedYes
dc.local.versionACCEPTED
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