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dc.contributor.authorRea, Kieran
dc.contributor.authorRoche, Michelle
dc.contributor.authorFinn, David P.
dc.date.accessioned2012-01-20T10:55:35Z
dc.date.available2012-01-20T10:55:35Z
dc.date.issued2011-04
dc.identifier.citationRea K, Roche M, Finn DP (2011). Modulation of conditioned fear, fear-conditioned analgesia and brain regional c-Fos expression following administration of muscimol into the rat basolateral amygdala. Journal of Pain, 12(6):712-21.en_US
dc.identifier.urihttp://hdl.handle.net/10379/2498
dc.description.abstractEvidence suggests that gamma-aminobutyric acid (GABA) signalling in the basolateral amygdala (BLA) is involved in pain, fear, and fear-conditioned analgesia (FCA). In this study, we investigated the effects of intra-BLA administration of the GABAA receptor agonist muscimol on the expression of conditioned-fear, formalin-evoked nociception, and fear-conditioned analgesia in rats, and the associated alterations in brain regional expression of the immediate early gene product and marker of neuronal activity, c-Fos. Formalin-evoked nociceptive behavior, conditioned-fear and fear-conditioned analgesia were apparent in animals receiving intra-BLA saline. Intra-BLA muscimol suppressed fear behavior and prevented fear-conditioned analgesia, but had no significant effect on the expression of formalin-evoked nociception. The suppression of fear behavior by intra-BLA muscimol was associated with increased c-Fos expression in the central nucleus of the amygdala (CeA) and throughout the periaqueductal grey (PAG). These intra-BLA muscimol-induced increases in c-Fos expression were abolished in rats receiving intraplantar formalin injection. These data suggest that alterations in neuronal activity in the CeA and PAG as a result of altered GABAergic signalling in the BLA may be involved in the behavioral expression of fear and associated analgesia. Furthermore, these alterations in neuronal activity are susceptible to modulation by formalin-evoked nociceptive input in a state-dependent manner.en_US
dc.formatapplication/pdfen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectAmygdalaen_US
dc.subjectMuscimolen_US
dc.subjectGABAen_US
dc.subjectReceptoren_US
dc.subjectFearen_US
dc.subjectPainen_US
dc.subjectAnalgesiaen_US
dc.subjectRaten_US
dc.subjectc-Fosen_US
dc.subjectPharmacology &Therapeuticsen_US
dc.titleModulation of Conditioned Fear, Fear-Conditioned Analgesia, and Brain Regional C-Fos Expression Following Administration of Muscimol into the Rat Basolateral Amygdalaen_US
dc.typeArticleen_US
dc.local.publishedsourcehttp://dx.doi.org/10.1016/j.jpain.2010.12.010en_US
dc.description.peer-reviewedpeer-revieweden_US
dc.contributor.funderSFIen_US
dc.contributor.funderIrish Health Research Boarden_US
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