Now showing items 1-3 of 3

  • DNA mediated chromatin pull-down for the study of chromatin replication 

    Kliszczak, Anna E.; Rainey, Michael D.; Harhen, Brendan; Santocanale, Corrado (2011)
    Chromatin replication involves duplicating DNA while maintaining epigenetic information. These processes are critical for genome stability and for preserving cell-type identity. Here we describe a simple experimental ...
  • Kinase Inhibitor against Quiescent and Proliferating CLL Cells 

    Natoni, Alessandro; Murill, Laura S.; Kliszczak, Anna E.; Samali, Afshin; Santocanale, Corrado (2011-07-18)
    In chronic lymphocytic leukemia (CLL) the proliferation rate and resistance to drug-induced apoptosis are recognized as important factors in the outcome of treatment. In this study, we assess the activity and the mechanism ...
  • Requirement for PLK1 kinase activity in the maintenance of a robust spindle assembly checkpoint 

    Maffini, Stefano; Rainey, Michael D.; Kaczmarczyk, Agnieszka; O'Connor, Aisling; Gaboriau, David; Musacchio, Andrea; Santocanale, Corrado (Company of Biologists, 2016)
    During mitotic arrest induced by microtubule targeting drugs, the weakening of the spindle assembly checkpoint (SAC) allows cells to progress through the cell cycle without chromosome segregation occurring. PLK1 kinase ...