Show simple item record

dc.contributor.authorPursell, Lisa
dc.contributor.authorSmith, Peter
dc.date.accessioned2011-11-11T16:28:31Z
dc.date.available2011-11-11T16:28:31Z
dc.date.issued2004-05-31
dc.identifier.citationCoyne, R., Samuelsen, O., Bergh, O., Andersen, K., Pursell, L., Dalsgaard, I., et al. (2004). On the validity of setting breakpoint minimum inhibition concentrations at one quarter of the plasma concentration achieved following oral administration of oxytetracycline. Aquaculture, 239(1-4), 23-35.en_US
dc.identifier.urihttp://hdl.handle.net/10379/2314
dc.description.abstractPlasma concentrations of oxytetracycline (OTC) were established in two Atlantic salmon (Salmo salar) pre-smolts populations after they had received OTC medicated feed at a rate of 75 mg OTC/kg over 10 days. One population was experiencing an epizootic of furunculosis in a commercial freshwater farm and the other was held in a laboratory. Both populations were maintained at approximately 13 jC. The mean plasma concentration in 26 health farm fish was 0.25F0.06 and the 80th percentile was 0.21 mg/l. The mean concentration for 26 laboratory fish was 0.21F0.06 mg/l with an 80th percentile of 0.15 mg/l. The validity of setting a breakpoint minimum inhibitory concentration (MIC) at a quarter of these plasma concentrations was investigated. The MIC of the Aeromonas salmonicida isolated from the farmed fish (n = 7) was 0.5 mg/l and the breakpoints generated by application of the 4:1 ratio were in the range 0.03125 - 0.0625 mg/l. These breakpoint values would, therefore, predict that the therapy should have had no beneficial effect and that any strain of A. salmonicida with MIC>0.0625 mg/l must be considered as resistant. A consideration of the pattern of the mortalities before and during the period of therapy suggests that the therapy was probably beneficial. Thus, the data obtained in this work suggest that the application of the 4:1 ratio is not a valid method of generating meaningful breakpoint MIC values.en_US
dc.formatapplication/pdfen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectOxytetracycline therapyen_US
dc.subjectBreakpointsen_US
dc.subjectMinimum inhibitory concentrationsen_US
dc.subjectPlasma concentrationsen_US
dc.subjectHealth Promotionen_US
dc.titleOn the validity of setting breakpoint minimum inhibition concentrations at one quarter of the plasma concentration achieved following oral administration of oxytetracyclineen_US
dc.typeArticleen_US
dc.local.publishedsourcehttp://dx.doi.org/10.1016/j.aquaculture.2004.05.036en_US
dc.description.peer-reviewedpeer-revieweden_US
dc.contributor.funderMarie Curie Fellowship (QLK2-CT-2000-51162)en_US
nui.item.downloads235


Files in this item

Attribution-NonCommercial-NoDerivs 3.0 Ireland
This item is available under the Attribution-NonCommercial-NoDerivs 3.0 Ireland. No item may be reproduced for commercial purposes. Please refer to the publisher's URL where this is made available, or to notes contained in the item itself. Other terms may apply.

The following license files are associated with this item:

Thumbnail

This item appears in the following Collection(s)

Show simple item record