Now showing items 1-6 of 6

  • Effects and mechanisms of action of sildenafil citrate in human chorionic arteries 

    Maharaj, Chrisen H.; O'Toole, Daniel; Lynch, Tadhg; Carney, John; Jarman, James; Higgins, Brendan D.; Morrison, John J.; Laffey, John G. (2009)
    Objectives Sildenafil citrate, a specific phosphodiesterase-5 inhibitor, is increasingly used for pulmonary hypertension in pregnancy. Sildenafil is also emerging as a potential candidate for the treatment of intra-uterine ...
  • Genetically Modified Mesenchymal Stem 

    Griffin, Matthew; Greiser, Udo; Barry, Frank; O'Brien, Timothy; Ritter, Thomas (2010-03)
    Adult mesenchymal stem cells (MSCs) are non-hematopoietic cells with multi-lineage potential to differentiate into various tissues of mesodermal origin. They can be isolated from bone marrow and other tissues and have the ...
  • Ghrelin in the human myometrium 

    O'Brien, Margaret; Earley, Padraig; Morrison, John J.; Smith, Terry (BioMed Central Ltd, 2010-03-29)
    Ghrelin is a 28-amino acid octanolyated peptide, synthesised primarily in the stomach. It stimulates growth hormone release, food intake and exhibits many other diverse effects. Our group have previously determined that ...
  • Hypertonic saline reduces inflammation and enhances the resolution of oleic acid induced acute lung injury 

    Kennedy, Muiris T; Higgins, Brendan D; Costello, Joseph F; Curtin, William A; Laffey, John G (BioMed Central Ltd., 2008-07-08)
    Background: Hypertonic saline (HTS) reduces the severity of lung injury in ischemia-reperfusion, endotoxin-induced and ventilation-induced lung injury. However, the potential for HTS to modulate the resolution of lung ...
  • Regulation of the DNA Damage Response and Gene Expression by the Dot1L Histone Methyltransferase and the 53Bp1 Tumour Suppressor 

    FitzGerald, Jennifer; Moureau, Sylvie; O'Connell, Enda; Grenon, Muriel; Muriel, Noel F. (PLoS, 2011-02)
    Background Dot1L, a histone methyltransferase that targets histone H3 lysine 79 (H3K79), has been implicated in gene regulation and the DNA damage response although its functions in these processes remain poorly ...
  • Trigger Factor from the Psychrophilic Bacterium Psychrobacter frigidicola Is a Monomeric Chaperone 

    Robin, Sylvain; Togashi, Denisio M.; Ryder, Alan G.; Wall, J. Gerard (American Society for Microbiology, 2009)
    In eubacteria, trigger factor (TF) is the first chaperone to interact with newly synthesized polypeptides and assist their folding as they emerge from the ribosome. We report the first characterization of a TF from a ...