Now showing items 1-4 of 4

  • Gene therapy in transplantation: Toward clinical trials 

    Ritter, Thomas (Thompson, 2009)
    The genetic modification of organs or cells is an attractive approach to protect allogeneic transplants from acute rejection and other complications. The transplant setting offers a unique opportunity to utilise ex vivo ...
  • Immunogenicity of allogeneic mesenchymal stem cells 

    Ritter, Thomas (2012)
    Mesenchymal stem cells (MSCs) inhibit proliferation of allogeneic T cells and express low levels of major histocompatibility complex class I (MHCI), MHCII and vascular adhesion molecule-1 (VCAM-1). We investigated whether ...
  • Non-viral gene therapy for myocardial engineering 

    Holladay, Carolyn A.; O'Brien, Timothy; Pandit, Abhay (John Wiley & Sons, Ltd., 2010-05)
    Despite significant advances in surgical and pharmacological techniques, myocardial infarction (MI) remains the main cause of morbidity in the developed world because no remedy has been found for the regeneration of infarcted ...
  • Thermosensitive hydrogel for prolonged delivery of lentiviral vector expressing neurotrophin-3 in vitro 

    McMahon, Siobhan; Nikolskaya, Natalia; Ní Choileain, Siobhan; Hennessy, Niamh; O'Brien, Timothy; Rochev, Yury (Wiley, 2011-11-01)
    Background The development of tissue engineering scaffolds for gene delivery has the potential to enhance gene transfer efficiency and safety via controlled temporal and spatial delivery. Lentiviral delivery can be carried ...