Browsing Research Institutes and Centres by Author "Barry, Frank"
Now showing items 1-8 of 8
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Differentiation of vascular stem cells contributes to ectopic calcification of atherosclerotic plaque
Leszczynska, Aleksandra; O'Doherty, Aideen; Farrell, Eric; Pindjakova, Jana; O'Brien, Fergal J.; O'Brien, Timothy; Barry, Frank; Murphy, Mary (Wiley, 2016-02-27)The cellular and molecular basis of vascular calcification (VC) in atherosclerosis is not fully understood. Here, we investigate role of resident/circulating progenitor cells in VC and contribution of inflammatory plaque ... -
Evaluation of cartilage repair by mesenchymal stem cells seeded on a PEOT/PBT scaffold in an osteochondral defect
Barron, Valerie; Merghani, Khalid; Shaw, Georgina; Coleman, Cynthia; Hayes, Jessica; Ansboro, Sharon; Manian, Abi; O'Malley, Grace; Connolly, Emma; Nandakumar, Ananda; Van Blitterswijk, Clemen; Habibovic, Pamela; Moroni, Lorenzo; Shannon, Fintan; Barry, Frank; Murphy, Mary (Springer Verlag, 2015-01-15)The main objective of this study was to evaluate the effectiveness of a mesenchymal stem cell (MSC)-seeded polyethylene-oxide-terephthalate/polybutylene-terephthalate (PEOT/PBT) scaffold for cartilage tissue repair in an ... -
Evaluation of the early in vivo response of a functionally graded macroporous scaffold in an osteochondral defect in a rabbit model
Barron, Valerie; Neary, Martin; Mohamed, Khalid Merghani Salid; Ansboro, Sharon; Shaw, Georgina; O'Malley, Grace; Rooney, Niall; Barry, Frank; Murphy, Mary (Springer Verlag, 2015-10-05)Cartilage tissue engineering is a multifactorial problem requiring a wide range of material property requirements from provision of biological cues to facilitation of mechanical support in load-bearing diarthrodial joints. ... -
Genetically Modified Mesenchymal Stem
Griffin, Matthew; Greiser, Udo; Barry, Frank; O'Brien, Timothy; Ritter, Thomas (2010-03)Adult mesenchymal stem cells (MSCs) are non-hematopoietic cells with multi-lineage potential to differentiate into various tissues of mesodermal origin. They can be isolated from bone marrow and other tissues and have the ... -
Induced pluripotent stem cells in companion animals: how can we move the field forward?
Barrachina, Laura; Arshaghi, Tarlan Eslami; O'Brien, Aisling; Ivanovska, Ana; Barry, Frank (Frontiers Media, 2023-04-25)Following a one medicine approach, the development of regenerative therapies for human patients leads to innovative treatments for animals, while pre-clinical studies on animals provide knowledge to advance human medicine. ... -
Mesenchymal stem cells and osteoarthritis: remedy or accomplice?
Coleman, Cynthia M.; Curtin, Caroline; Barry, Frank; O'Flatharta, Cathal; Murphy, Mary (Mary Ann Liebert, Inc., 2010-10)Multipotent mesenchymal stromal or stem cells (MSCs) are likely to be agents of connective tissue homeostasis and repair. Because the hallmark of osteoarthritis (OA) is degeneration and failure to repair connective tissues ... -
The motivational factors and adverse events experienced by healthy volunteers donating bone marrow for research
Ejiugwo, Mirella; Shaw, Georgina; Barry, Frank; Krawczyk, Janusz; McInerney, Veronica (Heighten Science Publications Corporation (HSPC), 2019-12-05)Background: With the advancement of cell therapy research, there is an increasing need for healthy volunteers (HV) to donate small volumes (30 ml) of human bone marrow (BM). The BM procedure required to procure small ... -
A novel high-throughput screening platform identifies itaconate derivatives from marine Penicillium antarcticum as inhibitors of mesenchymal stem cell differentiation
Marchese, Pietro; Mahajan, Nipun; O’Connell, Enda; Fearnhead, Howard; Tuohy, Maria; Krawczyk, Janusz; Thomas, Olivier P.; Barry, Frank; Murphy, Mary J. (MDPI, 2020-04-05)Worldwide diffused diseases such as osteoarthritis, atherosclerosis or chronic kidney disease are associated with a tissue calcification process which may involve unexpected local stem cell differentiation. Current ...