Now showing items 1-5 of 5

  • Differentiation of vascular stem cells contributes to ectopic calcification of atherosclerotic plaque 

    Leszczynska, Aleksandra; O'Doherty, Aideen; Farrell, Eric; Pindjakova, Jana; O'Brien, Fergal J.; O'Brien, Timothy; Barry, Frank; Murphy, Mary (Wiley, 2016-02-27)
    The cellular and molecular basis of vascular calcification (VC) in atherosclerosis is not fully understood. Here, we investigate role of resident/circulating progenitor cells in VC and contribution of inflammatory plaque ...
  • Evaluation of cartilage repair by mesenchymal stem cells seeded on a PEOT/PBT scaffold in an osteochondral defect 

    Barron, Valerie; Merghani, Khalid; Shaw, Georgina; Coleman, Cynthia; Hayes, Jessica; Ansboro, Sharon; Manian, Abi; O'Malley, Grace; Connolly, Emma; Nandakumar, Ananda; Van Blitterswijk, Clemen; Habibovic, Pamela; Moroni, Lorenzo; Shannon, Fintan; Barry, Frank; Murphy, Mary (Springer Verlag, 2015-01-15)
    The main objective of this study was to evaluate the effectiveness of a mesenchymal stem cell (MSC)-seeded polyethylene-oxide-terephthalate/polybutylene-terephthalate (PEOT/PBT) scaffold for cartilage tissue repair in an ...
  • Evaluation of the early in vivo response of a functionally graded macroporous scaffold in an osteochondral defect in a rabbit model 

    Barron, Valerie; Neary, Martin; Mohamed, Khalid Merghani Salid; Ansboro, Sharon; Shaw, Georgina; O'Malley, Grace; Rooney, Niall; Barry, Frank; Murphy, Mary (Springer Verlag, 2015-10-05)
    Cartilage tissue engineering is a multifactorial problem requiring a wide range of material property requirements from provision of biological cues to facilitation of mechanical support in load-bearing diarthrodial joints. ...
  • Genetically Modified Mesenchymal Stem 

    Griffin, Matthew; Greiser, Udo; Barry, Frank; O'Brien, Timothy; Ritter, Thomas (2010-03)
    Adult mesenchymal stem cells (MSCs) are non-hematopoietic cells with multi-lineage potential to differentiate into various tissues of mesodermal origin. They can be isolated from bone marrow and other tissues and have the ...
  • Mesenchymal stem cells and osteoarthritis: remedy or accomplice? 

    Coleman, Cynthia M.; Curtin, Caroline; Barry, Frank; O'Flatharta, Cathal; Murphy, Mary (Mary Ann Liebert, Inc., 2010-10)
    Multipotent mesenchymal stromal or stem cells (MSCs) are likely to be agents of connective tissue homeostasis and repair. Because the hallmark of osteoarthritis (OA) is degeneration and failure to repair connective tissues ...