Browsing Research Institutes and Centres by Author "Griffin, Matthew D."
Now showing items 1-15 of 15
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Anti-donor antibody induction following intramuscular injections of allogeneic mesenchymal stromal cells
Alagesan, Senthilkumar; Sanz‐Nogués, Clara; Chen, Xizhe; Creane, Michael; Ritter, Thomas; Ceredig, Rhodri; O'Brien, Timothy; Griffin, Matthew D. (Wiley, 2018-02-15)Allogeneic mesenchymal stromal cells (allo-MSC) are a promising "off-the-shelf" therapy with anti-inflammatory and pro-repair properties. This study investigated humoral immune responses to intramuscular (IM) injections ... -
Burden of chronic kidney disease and rapid decline in renal function among adults attending a hospital-based diabetes center in Northern Europe
Griffin, Tomás P.; O'Shea, Paula M.; Smyth, Andrew; Islam, Md Nahidul; Wall, Deirdre; Ferguson, John; O'Sullivan, Esther; Finucane, Francis M.; Dinneen, Sean F.; Dunne, Fidelma P.; Lappin, David W.; Reddan, Donal N.; Bell, Marcia; O'Brien, Timothy; Griffin, Damian G.; Griffin, Matthew D. (BMJ Publishing Group, 2021-06-14)Introduction This study aimed to determine the prevalence of diabetic kidney disease (DKD) and rapid renal function decline and to identify indices associated with this decline among adults attending a diabetes center in ... -
Defining reference intervals for a serum growth differentiation factor-15 (GDF-15) assay in a Caucasian population and its potential utility in diabetic kidney disease (DKD).
Hamon, Siobhan M.; Griffin, Tomás P.; Islam, Md Nahidul; Wall, Deirdre; Griffin, Matthew D.; O’Shea, Paula M. (De Gruyter, 2018-09-15)BACKGROUND: Growth differentiation factor-15 (GDF-15), a stress responsive cytokine, is a promising biomarker of renal functional decline in diabetic kidney disease (DKD). This study aimed primarily to establish normative ... -
Editorial: Innovative biologics and drugs to target renal inflammation
Griffin, Matthew D.; Swaminathan, Sundararaman (Frontiers Media, 2020-02-06)[No abstract available] -
Effect of sodium glucose co-transporter-2 inhibition on the Aldosterone/Renin Ratio in Type 2 Diabetes Mellitus
Griffin, Tomás P.; Islam, Md Nahidul; Blake, Liam; Bell, Marcia; Griffin, Matthew D.; O’Shea, Paula M. (Thieme Publishing, 2018-12-06)The aldosterone to renin ratio (ARR) is recommended for case detection of primary aldosteronism (PA). Several factors including medications can undermine its diagnostic accuracy. The objective was to explore the effect of ... -
Effects of mesenchymal stromal cells on regulatory T cells: Current understanding and clinical relevance
Negi, Neema; Griffin, Matthew D. (AlphaMed Press and Wiley, 2020-01-29)The immunomodulatory potential of mesenchymal stromal cells (MSCs) and regulatory T cells (T-reg) is well recognized by translational scientists in the field of regenerative medicine and cellular therapies. A wide range ... -
High-risk corneal transplantation: Recent developments and future possibilities
Armitage, W. John; Goodchild, Christine; Griffin, Matthew D.; Gunn, David J.; Hjortdal, Jesper; Lohan, Paul; Murphy, Conor C.; Pleyer, Uwe; Ritter, Thomas; Tole, Derek M.; Vabres, Bertrand (Lippincott, Williams & Wilkins, 2019-12)Human corneal transplantation (keratoplasty) is typically considered to have superior short- and long-term outcomes and lower requirement for immunosuppression compared to solid organ transplants because of the inherent ... -
Human mesenchymal stromal cells broadly modulate high glucose-induced inflammatory responses of renal proximal tubular cell monolayers
Islam, Md Nahidul; Griffin, Tomás P.; Sander, Elizabeth; Rocks, Stephanie; Qazi, Junaid; Cabral, Joana; McCaul, Jasmin; McMorrow, Tara; Griffin, Matthew D. (BMC, 2019-11-19)Background: Renal proximal tubular epithelial cells (RPTEC) are dysfunctional in diabetic kidney disease (DKD). Mesenchymal stromal cells (MSC) may modulate DKD pathogenesis through anti-inflammatory mediators. This study ... -
Human monocyte subset distinctions and function: Insights from gene expression analysis
Cormican, Sarah; Griffin, Matthew D. (Frontiers Media, 2020-06-04)Monocytes are a highly plastic innate immune cell population that displays significant heterogeneity within the circulation. Distinct patterns of surface marker expression have become accepted as a basis for distinguishing ... -
Increased weight gain during the long interdialytic period Is associated with minor effects on blood pressure control in clinically stable in-centre haemodialysis patients
Shantier, Mohamed; Martin, William P.; Singh, Rajneet; McDermott, Paul; Gallen, Rory; Suleiman, Sami; Reddan, Donal N.; Giblin, Louise; Lappin, David; O’Meara, Yvonne M.; Griffin, Matthew D. (Karger Publishers, 2018-11-09)Background/Aims: Three-day-a-week chronic haemodialysis (cHD) involves 1 long (72 h) and 2 short (48 h) inter-dialytic periods (IDPs), We aimed to determine whether BP control following the long IDP is inferior to the short ... -
Mesenchymal stromal cell–based therapies for acute kidney injury: progress in the last decade
Fazekas, Barbara; Griffin, Matthew D. (Elsevier, 2020-01-28)A little over 10 years ago, the therapeutic potential of mesenchymal stromal cells (MSCs) for the treatment of acute kidney injury (AKI) was becoming widely recognized. Since then, there has been further intensive study ... -
Phenotypic and functional heterogeneity of human intermediate monocytes based on HLA-DR expression
Connaughton, Eanna P.; Naicker, Serika; Hanley, Shirley A.; Slevin, Stephanie M.; Eykelenboom, John K.; Lowndes, Noel F.; O'Brien, Timothy; Ceredig, Rhodri; Griffin, Matthew D.; Dennedy, Michael C. (Wiley, 2018-03-05)Human blood monocytes are subclassified as classical, intermediate and nonclassical. In this study, it was shown that conventionally defined human intermediate monocytes can be divided into two distinct subpopulations with ... -
Plasma dephosphorylated-uncarboxylated Matrix Gla-Protein (dp-ucMGP): reference intervals in Caucasian adults and diabetic kidney disease biomarker potential
Griffin, Tomás Patrick; Islam, Md Nahidul; Wall, Deirdre; Ferguson, John; Griffin, Damian Gerard; Griffin, Matthew D.; O’Shea, Paula M. (Nature Research, 2019-12-05)Recent studies suggest a possible association between dephosphorylated-uncarboxylated MGP (dp-ucMGP) and glomerular filtration rate (GFR). This study aimed to establish normative data in an adult Caucasian population and ... -
Progress toward the clinical application of mesenchymal stromal cells and other disease-modulating regenerative therapies
Hickson, LaTonya J.; Herrmann, Sandra M.; McNicholas, Bairbre A.; Griffin, Matthew D. (American Society of Nephrology, 2021-01-27)Drawing from basic knowledge of stem cell biology, embryonic development, wound healing and aging, regenerative medicine seeks to develop therapeutic strategies that complement or replace conventional treatments by actively ... -
TGF-ß1-Licensed Murine MSCs show superior therapeutic efficacy in modulating corneal allograft immune rejection In Vivo
Lynch, Kevin; Treacy, Oliver; Chen, Xizhe; Murphy, Nick; Lohan, Paul; Islam, Md Nahidul; Donohoe, Ellen; Griffin, Matthew D.; Watson, Luke; McLoughlin, Steven; O'Malley, Grace; Ryan, Aideen E.; Ritter, Thomas (Elsevier, 2020-05-29)Mesenchymal stromal cells (MSCs) are a promising therapeutic option for multiple immune diseases/disorders; however, efficacy of MSC treatments can vary significantly. We present a novel licensing strategy to improve the ...