Browsing Research Institutes and Centres by Author "Creane, Michael"
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Anti-donor antibody induction following intramuscular injections of allogeneic mesenchymal stromal cells
Alagesan, Senthilkumar; Sanz‐Nogués, Clara; Chen, Xizhe; Creane, Michael; Ritter, Thomas; Ceredig, Rhodri; O'Brien, Timothy; Griffin, Matthew D. (Wiley, 2018-02-15)Allogeneic mesenchymal stromal cells (allo-MSC) are a promising "off-the-shelf" therapy with anti-inflammatory and pro-repair properties. This study investigated humoral immune responses to intramuscular (IM) injections ... -
Biodistribution and retention of locally administered human mesenchymal stromal cells: Quantitative polymerase chain reaction–based detection of human DNA in murine organs
Creane, Michael; Howard, Linda; O'Brien, Timothy; Coleman, Cynthia M. (Elsevier, 2017-01-12)Background. Determining the distributive fate and retention of a cell therapy product after administration is an essential part of characterizing it's biosafety profile. Therefore, regulatory guidelines stipulate that ...