Browsing Physiology by Author "Burke, Nikita N."
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Altered neuropathic pain behaviour in a rat model of depression is associated with changes in inflammatory gene expression in the amygdala
Burke, Nikita N.; Geoghegan, E.; Moriarty, Orla; Finn, David P.; Kerr, Daniel M.; Roche, Michelle (Wiley, 2013-08-29)The association between chronic pain and depression is widely recognized, the comorbidity of which leads to a heavier disease burden, increased disability and poor treatment response. This study examined nociceptive ... -
Chronic administration of amitriptyline differentially alters neuropathic pain-related behaviour in the presence and absence of a depressive-like phenotype
Burke, Nikita N.; Finn, David P.; Roche, Michelle (Elsevier, 2015-02)Chronic pain and depression share a complex, reciprocal relationship. Furthermore, in addition to treating depression, antidepressants such as amitriptyline are a first-line treatment for chronic pain conditions, indicating ... -
Chronic administration of buprenorphine in combination with samidorphan produces sustained effects in olfactory bulbectomised rats and Wistar-Kyoto rats
Burke, Nikita N.; Li, Yan; Daniel R Deaver, Daniel R.; Deaver, Daniel R.; Finn, David P.; Roche, Michelle; Eyerman, David J.; Sanchez, Connie; Kelly, John P. (SAGE Publications, 2019-09-12)Background: The combination of buprenorphine, a partial mu-opioid receptor agonist and a functional kappa-opioid receptor antagonist, with samidorphan, a functional mu-opioid receptor antagonist, is being developed as an ... -
The development of translational biomarkers as a tool for improving the understanding, diagnosis and treatment of chronic neuropathic pain
Buckley, David A.; Jennings, Elaine M.; Burke, Nikita N.; Roche, Michelle; McInerney, Veronica; Wren, Jonathan D.; Finn, David P.; McHugh, Patrick C. (Springer, 2017-03-30)Chronic neuropathic pain (CNP) is one of the most significant unmet clinical needs in modern medicine. Alongside the lack of effective treatments, there is a great deficit in the availability of objective diagnostic methods ... -
Maternal deprivation is associated with sex-dependent alterations in nociceptive behavior and neuroinflammatory mediators in the rat following peripheral nerve injury
Burke, Nikita N.; Llorente, Ricardo; Marco, Eva M.; Tong, Kezanne; Finn, David P.; Viveros, Maria-Paz; Roche, Michelle (Elsevier, 2013-10)Early-life stress is associated with an increased risk of developing affective disorders and chronic pain conditions. This study examined the effect of maternal deprivation (MD) on nociceptive responding prior to and ... -
Minocycline modulates neuropathic pain behaviour and cortical M1-M2 microglial gene expression in a rat model of depression
Burke, Nikita N.; Kerr, Daniel M.; Moriarty, Orla; Finn, David P.; Roche, Martin (Elsevier, 2014-11)There is a paucity of data on the role of microglia and neuroinflammatory processes in the association between chronic pain and depression. The current study examined the effect of the microglial inhibitor minocycline on ... -
Neuroinflammatory mechanisms linking pain and depression
Burke, Nikita N.; Finn, David P.; Roche, Michelle (Karger, 2015)Depression and chronic pain have been estimated to co-occur in up to 80% of patients suffering from these disorders, with this co-morbidity being more disabling and more expensive to both patients and society than either ... -
Psychological stress in early life as a predisposing factor for the development of chronic pain: Clinical and preclinical evidence and neurobiological mechanisms
Burke, Nikita N.; Finn, David P.; McGuire, Brian E.; Roche, Michelle (Wiley, 2016-07-12)A wealth of research over the past 2 decades has expanded our understanding of the impact of early-life adversity on physiological function and, consequently, health and wellbeing in later life. Early-life adversity increases ... -
Sex differences and similarities in depressive-and anxiety-like behaviour in the Wistar-Kyoto rat
Burke, Nikita N.; Coppinger, Jonathan; Deaver, Daniel R.; Roche, Michelle; Finn, David P.; Kelly, John (Elsevier, 2016-08-31)Depression is a debilitating psychiatric disorder that is highly comorbid with anxiety. Depression is twice as prevalent in women as in men, however, females remain underrepresented in preclinical research. The stress ...