Browsing Physiology by Title
Now showing items 22-41 of 73
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Effect of a binge-like dosing regimen of methamphetamine on dopamine levels and tyrosine hydroxylase expressing neurons in the rat brain
(Elsevier, 2018-10-05)Methamphetamine, an amphetamine derivative, is a powerful psychomotor stimulant and commonly used drug of abuse. This study examined the effect of binge-like methamphetamine (MA) dosing (4 x 4 mg/kg, s.c., 2 h apart) on ... -
Effect of N1-Dansylspermine and Ro25,6981 on locomotor activity in naive mice and in the resperpinised mouse model of Parkinson's disease
(Lippincott, Williams & Wilkins, 2016-09-01)The effect of N1-dansylspermine, a polyamine analogue and competitive polyamine antagonist, and Ro25,6981, a noncompetitive polyamine antagonist with good affinity and selectivity for the GluN2B subunit, on locomotor ... -
Endocannabinoid modulation of inflammatory hyperalgesia in the IFN-α mouse model of depression
(Elsevier, 2019-09-07)Depression is a well-recognised effect of long-term treatment with interferon-alpha (IFN-alpha), a widely used treatment for chronic viral hepatitis and malignancy. In addition to the emotional disturbances, high incidences ... -
Evaluation of the Finis Swimsense (R) and the Garmin Swim (TM) activity monitors for swimming performance and stroke kinematics analysis
(Public Library of Science, 2017-02-08)Aims The study aims were to evaluate the validity of two commercially available swimming activity monitors for quantifying temporal and kinematic swimming variables. Methods Ten national level swimmers (5 male, 5 female; ... -
Exacerbated LPS/GalN-induced liver injury in the stress-sensitive Wistar Kyoto rat is associated with changes in the endocannabinoid system
(MDPI, 2020-08-23)Acute liver injury (ALI) is a highly destructive and potentially life-threatening condition, exacerbated by physical and psychological stress. The endocannabinoid system plays a key role in modulating stress and hepatic ... -
FAAH inhibition attenuates TLR3-mediated hyperthermia, nociceptive- and anxiety-like behaviour in female rats
(Elsevier, 2018-06-25)Aberrant activation of toll-like receptor (TLR)s results in persistent and prolonged neuroinflammation and has been implicated in the pathogenesis and exacerbation of psychiatric and neurodegenerative disorders. TLR3 ... -
FAAH, but not MAGL, inhibition modulates acute TLR3‐induced neuroimmune signaling in the rat, independent of sex
(Wiley, 2017-07-20)Toll-like receptor (TLR)3 is a key component of the innate immune response to viral infection. The present study firstly examined whether sex differences exist in TLR3-induced inflammatory, endocrine, and sickness responses. ... -
Fatty acid binding protein expression in clots retrieved by mechanical thrombectomy from patients with acute ischaemic stroke
(Sage Publications, 2019-05-22)Introduction: Lipid accumulation and inflammation are considered hallmarks of the unstable atherosclerotic plaque. In particular, adipocyte fatty acid binding protein (FABP4) expression within the plaque is associated ... -
For whom the endocannabinoid tolls: Modulation of innate immune function and implications for psychiatric disorders
(Elsevier, 2015-03-17)Toll-like receptors (TLRs) mediate the innate immune response to pathogens and are critical in the host defence, homeostasis and response to injury. However, uncontrolled and aberrant TLR activation can elicit potent effects ... -
High CerS5 expression levels associate with reduced patient survival and transition from apoptotic to autophagy signalling pathways in colorectal cancer
(Wiley, 2014-11-13)Ceramide synthase 5 is involved in the de novo synthesis of ceramide, a sphingolipid involved in cell death and proliferation. In this study, we investigated the role of ceramide synthase 5 in colorectal cancer by examining ... -
High times for painful blues: the endocannabinoid system in pain-depression comorbidity
(Oxford University Press (OUP), 2015-09-05)Depression and pain are two of the most debilitating disorders worldwide and have an estimated cooccurrence of up to 80%. Comorbidity of these disorders is more difficult to treat, associated with significant disability ... -
Histological characterization of white clots retrieved by mechanical thrombectomy from acute ischemic stroke patients
(SAGE Publications, 2019-01-01)Introduction: Advances in mechanical thrombectomy have created the unique opportunity to study the acute ischemic stroke clot material. However, there is a lack of uniformity in the histopathologic characterization of ... -
Histological stroke clot analysis after thrombectomy: Technical aspects and recommendations
(SAGE Publications, 2019-11-03)The recent advent of endovascular procedures has created the unique opportunity to collect and analyze thrombi removed from cerebral arteries, instigating a novel subfield in stroke research. Insights into thrombus ... -
Home detection of freezing of gait using support vector machines through a single waist-worn triaxial accelerometer
(Public Library of Science, 2017-02-15)Among Parkinson's disease (PD) symptoms, freezing of gait (FoG) is one of the most debilitating. To assess FoG, current clinical practice mostly employs repeated evaluations over weeks and months based on questionnaires, ... -
Hydroxycinnamic acid amide derivatives of polyamines reverse spermine-induced CNS excitation
(Elsevier, 2015-03-28)The aim of this study was to examine the acute effect of a range of novel hydroxycinnamic acid derivatives of spermine on the development of spermine-induced CNS excitation and convulsions in female Laca mice, and to assess ... -
The impact of occlusion location and bridging therapy in patients affected by acute ischemic stroke in determining the total number of passes required to remove the clot and the final revascularization outcome
(WFITN (World Federation of Interventional and Therapeutic Neuroradiology), 2019-10-21)Purpose Our purpose was to assess the impact of occlusion location in patients suffering from Acute Ischemic Stroke (AIS) on the total number of passes (attempts) necessary to retrieve the clot and on final revascularization ... -
Inertial sensor technology for elite swimming performance analysis: a systematic review
(MDPI, 2015-12-25)Technical evaluation of swimming performance is an essential factor of elite athletic preparation. Novel methods of analysis, incorporating body worn inertial sensors (i.e., Microelectromechanical systems, or MEMS, ... -
Kappa opioid receptor-mediated modulation of social responding in adolescent rats and in rats prenatally exposed to valproic acid
(Elsevier, 2020-08-05)The kappa opioid receptor (KOP) system modulates social play responding, however a paucity of studies have examined effects on social motivation and cognition in the absence of play. Prenatal exposure to the anti epileptic ... -
Large artery atherosclerotic clots are larger than clots of other stroke etiologies and have poorer recanalization rates
(Elsevier, 2020-11-24)Objectives There is a paucity of knowledge in the literature relating to the extent of clot burden and stroke etiology. In this study, we measured the Extracted Clot Area (ECA) retrieved during endovascular treatment (EVT) ... -
Maternal deprivation is associated with sex-dependent alterations in nociceptive behavior and neuroinflammatory mediators in the rat following peripheral nerve injury
(Elsevier, 2013-10)Early-life stress is associated with an increased risk of developing affective disorders and chronic pain conditions. This study examined the effect of maternal deprivation (MD) on nociceptive responding prior to and ...