Browsing College of Engineering and Informatics by Author "Zeugolis, Dimitrios I."
Now showing items 1-7 of 7
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A Biomaterial Approach to Peripheral Nerve Regeneration: Bridging the Peripheral Nerve Gap and Enhancing Functional Recovery
Daly, William; Yao, Li; Zeugolis, Dimitrios I.; Pandit, Abhay (The Royal Society, 2011-11)Microsurgical techniques for the treatment of large peripheral nerve injuries (such as the gold standard autograft) and its main clinically approved alternative 'hollow nerve guidance conduits (NGCs)' have a number of ... -
The effect of intraluminal contact mediated guidance signals on axonal mismatch during peripheral nerve repair
Daly, William T.; Yao, Li; Abu-Rub, Mohammad; Zeugolis, Dimitrios I. (Elsevier, 2012-06-25)The current microsurgical gold standard for repairing long gap nerve injuries is the autograft. Autograft provides a protective environment for repair and a natural internal architecture, which is essential for regeneration. ... -
Electro-spinning of pure collagen nano-fibres – Just an expensive way to make gelatin?
Zeugolis, Dimitrios I.; Khew, Shih T.; Yew, Elijah S.Y.; Ekaputra, Andrew K.; Tong, Yen W.; Yung, Lin-Yue L.; Hutmacher, Dietmar W.; Sheppard, Colin; Raghunath, Michael (Elsevier, 2008-03-03)Scaffolds manufactured from biological materials promise better clinical functionality, providing that characteristic features are preserved. Collagen, a prominent biopolymer, is used extensively for tissue engineering ... -
Electromechanical properties of dried tendon and isoelectrically focused collagen hydrogels
Abu-Rub, Mohammad; Zeugolis, Dimitrios I.; Pandit, Abhay (Elsevier, 2012-08)Assembling artificial collagenous tissues with structural, functional, and mechanical properties which mimic natural tissues is of vital importance for many tissue engineering applications. While the electro-mechanical ... -
Macromolecular crowding meets tissue engineering by self-ssembly: A paradigm shift in regenerative medicine
Satyam, Abhigyan; Kumar, Pramod; Fan, Xingliang; Gorelov, Alexander; Rochev, Yury; Joshi, Lokesh; Peinado, Héctor; Lyden, David; Thomas, Benjamin; Rodriguez, Brian; Raghunath, Michael; Pandit, Abhay; Zeugolis, Dimitrios I. (Wiley, 2014-02-06)Advancements in molecular and cell biology have led to the development of cell-based therapies to treat injured or degenerated tissues. [1] The rationale of this concept is that functional regeneration can be achieved ... -
The past, present and future in scaffold-based tendon treatments
Lomas, A.J.; Ryan, C.N.M.; Sorushanova, A.; Shologu, N.; Sideri, A.I.; Tsioli, V.; Fthenakis, G.C.; Tzora, A.; Skoufos, I.; Quinlan, Leo R.; Ó Laighin, Gearóid; Mullen, A.M.; Kelly, A.M.; Kearns, J.L.; Biggs, S.; Pandit, Abhay; Zeugolis, Dimitrios I. (Elsevier, 2015-04)Tendon injuries represent a significant clinical burden on healthcare systems worldwide. As the human population ages and the life expectancy increases, tendon injuries will become more prevalent especially among young ... -
Preferential cell response to anisotropic electro-spun fibrous scaffolds under tension-free conditions
Pandit, Abhay; Zeugolis, Dimitrios I. (Springer, 2010-11)Anisotropic alignment of collagen fibres in musculoskeletal tissues is responsible for the resistance to mechanical loading, whilst in cornea is responsible for transparency. Herein, we evaluated the response of tenocytes, ...