Browsing College of Engineering and Informatics by Author "Vaughan, Ted J."
Now showing items 1-11 of 11
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Are all osteocytes equal? Multiscale modelling of cortical bone to characterise the mechanical stimulation of osteocytes
Vaughan, Ted J.; Verbruggen, Stefaan W.; McNamara, Laoise M. (Wiley, 2013-12-03)Bone continuously adapts its internal structure to accommodate the functional demands of its mechanical environment. This process is orchestrated by a network of mechanosensitive osteocytes that respond to external ... -
A combined experimental-numerical approach for generating statistically equivalent fibre distributions for high strength laminated composite materials
McCarthy, Conor T.; Vaughan, Ted J. (Elsevier, 2009-11-04)A technique is presented where actual experimental distributions, measured from a high strength carbon fibre composite, are considered in the development of a novel method to generate statistically equivalent fibre ... -
The effect of substrate stiffness, thickness, and cross-linking density on osteogenic cell behavior
Mullen, Conleth A.; Vaughan, Ted J.; Billiar, Kristen L.; McNamara, Laoise M. (Biophysical Society, 2015-04-07)Osteogenic cells respond to mechanical changes in their environment by altering their spread area, morphology, and gene expression profile. In particular, the bulk modulus of the substrate, as well as its microstructure ... -
An enhanced phenomenological model to predict surface-based localised corrosion of magnesium alloys for medical use
Quinn, Conall; Van Gaalen, Kerstin; McHugh, Peter E.; Kopp, Alexander; Vaughan, Ted J. (Elsevier, 2023-01-05)This study developed an enhanced phenomenological model for the predictions of surface-based localised corrosion of magnesium alloys for use in medical applications. The modelling framework extended previous surface-based ... -
Fluid flow in the osteocyte mechanical environment: a fluid-structure interaction approach
Verbruggen, Stefaan W.; Vaughan, Ted J.; McNamara, Laoise M. (Springer Verlag, 2013-04-09)Osteocytes are believed to be the primary sensor of mechanical stimuli in bone, which orchestrate osteoblasts and osteoclasts to adapt bone structure and composition to meet physiological loading demands. Experimental ... -
Mechanisms of osteocyte stimulation in osteoporosis
Verbruggen, Stefaan W.; Vaughan, Ted J.; McNamara, Laoise M. (Elsevier, 2016-05-10)Experimental studies have shown that primary osteoporosis' caused by oestrogen deficiency results in localised alterations in bone tissue properties and mineral composition. Additionally, changes to the lacunar-canalicular ... -
Multiscale fluid-structure interaction modelling to determine the mechanical stimulation of bone cells in a tissue engineered scaffold
Zhao, Feihu; Vaughan, Ted J.; McNamara, Laoise M. (2015-04)Recent studies have shown that mechanical stimulation, by means of flow perfusion and mechanical compression (or stretching), enhances osteogenic differentiation of mesenchymal stem cells and bone cells within biomaterial ... -
Quantification of fluid shear stress in bone tissue engineering scaffolds with spherical and cubical pore architectures
Zhao, Feihu; Vaughan, Ted J.; McNamara, Laoise M. (Springer Verlag, 2016-06)Recent studies have shown that mechanical stimulation, in the form of fluid perfusion and mechanical compression, can enhance osteogenic differentiation of mesenchymal stem cells and bone cells within tissue engineering ... -
The role of integrin αVβ3 in osteocyte mechanotransduction
Haugh, Matthew G.; Vaughan, Ted J.; McNamara, Laoise M. (Elsevier, 2014-11-10)Recent in vivo studies have proposed that integrin alpha(v)beta(3) attachments between osteocyte cell processes and the extracellular matrix may facilitate mechanosensation in bone. However the role of these attachments ... -
Strain amplification in bone mechanobiology: a computational investigation of the in vivo mechanics of osteocytes
Verbruggen, Stefaan W.; Vaughan, Ted J.; McNamara, Laoise M. (The Royal Society Publishing, 2012-06-06)The osteocyte is believed to act as the main sensor of mechanical stimulus in bone, controlling signalling for bone growth and resorption in response to changes in the mechanical demands placed on our bones throughout life. ... -
A three-scale finite element investigation into the effects of tissue mineralisation and lamellar organisation in human cortical and trabecular bone
Vaughan, Ted J.; McCarthy, Conor T.; McNamara, Laoise M. (Elsevier, 2012-03-20)Bone is an exceptional material that is lightweight for efficient movement but also exhibits excellent strength and stiffness imparted by a composite material of organic proteins and mineral crystals that are intricately ...