Browsing College of Engineering and Informatics by Subject "Strain amplification"

Now showing items 1-3 of 3

    • Fluid flow in the osteocyte mechanical environment: a fluid-structure interaction approach 

      Verbruggen, Stefaan W.; Vaughan, Ted J.; McNamara, Laoise M. (Springer Verlag, 2013-04-09)
      Osteocytes are believed to be the primary sensor of mechanical stimuli in bone, which orchestrate osteoblasts and osteoclasts to adapt bone structure and composition to meet physiological loading demands. Experimental ...

    • Mechanisms of osteocyte stimulation in osteoporosis 

      Verbruggen, Stefaan W.; Vaughan, Ted J.; McNamara, Laoise M. (Elsevier, 2016-05-10)
      Experimental studies have shown that primary osteoporosis' caused by oestrogen deficiency results in localised alterations in bone tissue properties and mineral composition. Additionally, changes to the lacunar-canalicular ...

    • Osteocyte differentiation and the formation of an interconnected cellular network in vitro 

      Mc Garrigle, M.J.; Mullen, Conleth A.; Haugh, Matthew G.; Voisin, Muriel C.; McNamara, Laoise M. (AO Research Institute Davos, 2016-05-26)
      Extracellular matrix (ECM) stiffness and cell density can regulate osteoblast differentiation in two dimensional environments. However, it is not yet known how osteoblast-osteocyte differentiation is regulated within a 3D ...