Browsing College of Engineering and Informatics by Author "Ronan, William"
Now showing items 1-15 of 15
-
Cellular contractility and substrate elasticity: a numerical investigation of the actin cytoskeleton and cell adhesion
Ronan, William; Deshpande, Vikram S.; McMeeking, Robert M.; McGarry, J. Patrick (Springer Verlag, 2013-06-18)Numerous experimental studies have established that cells can sense the stiffness of underlying substrates and have quantified the effect of substrate stiffness on stress fibre formation, focal adhesion area, cell traction, ... -
A comparison of two quasi-static computational models for assessment of intra-myocardial injection as a therapeutic strategy for heart failure
Fan, Yiling; Ronan, William; Teh, Irvin; Schneider, Jurgen E.; Varela, Claudia E.; Whyte, William; McHugh, Peter; Leen, Sean B.; Roche, Ellen (Wiley, 2019-05-06)Myocardial infarction, or heart attack, is the leading cause of mortality globally. Although the treatment of myocardial infarct has improved significantly, scar tissue that persists can often lead to increased stress and ... -
Computational investigation of in situ chondrocyte deformation and actin cytoskeleton remodelling under physiological loading
Dowling, Enda P.; Ronan, William; McGarry, J. Patrick (Elsevier, 2012-12-24)Previous experimental studies have determined local strain fields for both healthy and degenerate cartilage tissue during mechanical loading. However, the biomechanical response of chondrocytes in situ, in particular the ... -
Cooperative contractility: the role of stress fibres in the regulation of cell-cell junctions
Ronan, William; McMeeking, Robert M.; Chen, Christopher S.; Deshpande, Vikram S. (Elsevier, 2014-11-27)We present simulations of cell-cell adhesion as reported in a recent study [Liu et al., 2010, PNAS, 107(22), 9944-9] for two cells seeded on an array of micro-posts. The micro-post array allows for the measurement of forces ... -
The effect of remodelling and contractility of the actin cytoskeleton on the shear resistance of single cells: a computational and experimental investigation
Dowling, Enda P.; Ronan, William; Ofek, Gidon; Deshpande, Vikram S.; McMeeking, Robert M.; Athanasiou, Kyriacos A. (The Royal Society Publishing, 2012-07-18)The biomechanisms that govern the response of chondrocytes to mechanical stimuli are poorly understood. In this study, a series of in vitro tests are performed, in which single chondrocytes are subjected to shear deformation ... -
Effects of material thickness and processing method on poly(lactic-co-glycolic acid) degradation and mechanical performance
Shirazi, Reyhaneh Neghabat; Aldabbagh, Fawaz; Ronan, William; Erxleben, Andrea; Rochev, Yury; McHugh, Peter (Springer Verlag, 2016-09-02)In this study, the effects of material thickness and processing method on the degradation rate and the changes in the mechanical properties of poly(lactic-co-glycolic acid) material during simulated physiological degradation ... -
Experimental and computational investigation of the role of stress fiber contractility in the resistance of osteoblasts to compression
McGarry, J. Patrick; Weafer, Paul; Jarvis, S. P.; Ronan, William (2013)The mechanical behavior of the actin cytoskeleton has previously been investigated using both experimental and computational techniques. However, these investigations have not elucidated the role the cytoskeleton plays in ... -
Modelling the degradation and elastic properties of poly(lactic-co-glycolic acid) films and regular open -cell tissue engineering scaffolds
Shirazi, Reyhaneh Neghabat; Ronan, William; Rochev, Yury; McHugh, Peter (Elsevier, 2015-09-02)Scaffolding plays a critical rule in tissue engineering and an appropriate degradation rate and sufficient mechanical integrity are required during degradation and healing of tissue. This paper presents a computational ... -
Numerical investigation of the active role of the actin cytoskeleton in the compression resistance of cells
Ronan, William; McGarry, J. Patrick (Elsevier ScienceDirect, 2012-06-21)Numerous in-vitro studies have established that cells react to their physical environment and to applied mechanical loading. However, the mechanisms underlying such phenomena are poorly understood. Previous modelling of ... -
On the role of the actin cytoskeleton and nucleus in the biomechanical response of spread cells
Reynolds, Noel H.; Ronan, William; Dowling, Enda P.; McMeeking, Robert M.; McGarry, J. Patrick (Elsevier, 2014-02-11)Micropipette aspiration (MA) has been used extensively in biomechanical investigations of un-adhered cells suspended in media. In the current study, a custom MA system is developed to aspirate substrate adhered spread ... -
A review of the integrity of metallic vehicle armour to projectile attack
Lenihan, Donncha; Ronan, William; O'Donoghue, Padraic E.; Leen, Sean B. (SAGE Publications, 2018-02-28)This article presents a review of engineering and design aspects relevant to the mechanical and structural integrity of military vehicular armour, including materials-related technologies. Theoretical, experimental and ... -
Simulation of the Mechanical Response of Cells on Micropost Substrates
Ronan, William; McGarry, Patrick (American Society of Mechanical Engineers, 2013-09-20)Experimental studies where cells are seeded on micropost arrays in order to quantify their contractile behavior are becoming increasingly common. Interpretation of the data generated by this experimental technique is ... -
Stability enhancement of an atomic force microscope for long-term force measurement including cantilever modification for whole cell deformation
McGarry, J. Patrick; Weafer, Paul; Ronan, William; Nolan, D. R. (2012)Atomic force microscopy (AFM) is widely used in the study of both morphology and mechanical properties of living cells under physiologically relevant conditions. However, quantitative experiments on timescales of minutes ... -
The tensile ductility of cellular solids: the role of imperfections
Ronan, William; Deshpande, Vikram S.; Fleck, Norman A. (Elsevier, 2016-10-11)Metallic and polymeric foams typically possess a low tensile failure strain of a few percent despite the fact that the parent solid can have high ductility (10% or more). This is remarkable as foams are bending-dominated ... -
A thermodynamically motivated model for stress-fiber reorganization
Vigliotti, A.; Ronan, William; Baaijens, F.P.T.; Deshpande, V.S. (Springer Verlag, 2015-09-04)We present a model for stress-fiber reorganization and the associated contractility that includes both the kinetics of stress-fiber formation and dissociation as well as the kinetics of stress-fiber remodeling. These ...