Browsing College of Engineering and Informatics by Author "Dowling, Enda P."
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Computational investigation of in situ chondrocyte deformation and actin cytoskeleton remodelling under physiological loading
Dowling, Enda P.; Ronan, William; McGarry, J. Patrick (Elsevier, 2012-12-24)Previous experimental studies have determined local strain fields for both healthy and degenerate cartilage tissue during mechanical loading. However, the biomechanical response of chondrocytes in situ, in particular the ... -
The effect of remodelling and contractility of the actin cytoskeleton on the shear resistance of single cells: a computational and experimental investigation
Dowling, Enda P.; Ronan, William; Ofek, Gidon; Deshpande, Vikram S.; McMeeking, Robert M.; Athanasiou, Kyriacos A. (The Royal Society Publishing, 2012-07-18)The biomechanisms that govern the response of chondrocytes to mechanical stimuli are poorly understood. In this study, a series of in vitro tests are performed, in which single chondrocytes are subjected to shear deformation ... -
On the role of the actin cytoskeleton and nucleus in the biomechanical response of spread cells
Reynolds, Noel H.; Ronan, William; Dowling, Enda P.; McMeeking, Robert M.; McGarry, J. Patrick (Elsevier, 2014-02-11)Micropipette aspiration (MA) has been used extensively in biomechanical investigations of un-adhered cells suspended in media. In the current study, a custom MA system is developed to aspirate substrate adhered spread ...