Browsing College of Engineering and Informatics by Author "Voisin, Muriel C."
Now showing items 1-5 of 5
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Altered mechanical environment of bone cells in an animal model of short- and long-term osteoporosis
Verbruggen, Stefaan W.; McGarrigle, Myles J.; Haugh, Matthew G.; Voisin, Muriel C.; McNamara, Laoise M. (Biophysical Society, 2015-04-07)Alterations in bone tissue composition during osteoporosis likely disrupt the mechanical environment of bone cells and may thereby initiate a mechanobiological response. It has proved challenging to characterize the ... -
Differential β3 and β1 integrin expression in bone marrow and cortical bone of estrogen deficient rats
Voisin, Muriel C.; McNamara, Laoise M. (Wiley, 2015-08-12)Integrin-based (beta(3)) attachments to the extracellular matrix (ECM) on osteocyte cell processes have recently been proposed to play an important role in facilitating osteocyte mechanosensation. However, it is not yet ... -
Osteocyte differentiation and the formation of an interconnected cellular network in vitro
Mc Garrigle, M.J.; Mullen, Conleth A.; Haugh, Matthew G.; Voisin, Muriel C.; McNamara, Laoise M. (AO Research Institute Davos, 2016-05-26)Extracellular matrix (ECM) stiffness and cell density can regulate osteoblast differentiation in two dimensional environments. However, it is not yet known how osteoblast-osteocyte differentiation is regulated within a 3D ... -
Primary cilia exist in a small fraction of cells in trabecular bone and marrow
Coughlin, Thomas R.; Voisin, Muriel C.; Schaffler, Mitchell B.; Niebur, Glen L.; McNamara, Laoise M. (Springer, 2014-11-15)Primary cilia are potent mechanical and chemical sensory organelles in cells of bone lineage in tissue culture. Cell culture experiments suggest that primary cilia sense fluid flow and this stimulus is translated through ... -
Thermally induced osteocyte damage initiates a remodelling signaling cascade
Dolan, Eimear B.; Haugh, Margaret; Voisin, Muriel C.; Tallon, David; McNamara, Laoise M. (Public Library of Science, 2015-03-18)Thermal elevations experienced by bone during orthopaedic procedures, such as cutting and drilling, exothermal reactions from bone cement, and thermal therapies such as tumor ablation, can result in thermal damage leading ...