Browsing College of Engineering and Informatics by Author "Verbruggen, Stefaan W."
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Altered mechanical environment of bone cells in an animal model of short- and long-term osteoporosis
Verbruggen, Stefaan W.; McGarrigle, Myles J.; Haugh, Matthew G.; Voisin, Muriel C.; McNamara, Laoise M. (Biophysical Society, 2015-04-07)Alterations in bone tissue composition during osteoporosis likely disrupt the mechanical environment of bone cells and may thereby initiate a mechanobiological response. It has proved challenging to characterize the ... -
Are all osteocytes equal? Multiscale modelling of cortical bone to characterise the mechanical stimulation of osteocytes
Vaughan, Ted J.; Verbruggen, Stefaan W.; McNamara, Laoise M. (Wiley, 2013-12-03)Bone continuously adapts its internal structure to accommodate the functional demands of its mechanical environment. This process is orchestrated by a network of mechanosensitive osteocytes that respond to external ... -
Fluid flow in the osteocyte mechanical environment: a fluid-structure interaction approach
Verbruggen, Stefaan W.; Vaughan, Ted J.; McNamara, Laoise M. (Springer Verlag, 2013-04-09)Osteocytes are believed to be the primary sensor of mechanical stimuli in bone, which orchestrate osteoblasts and osteoclasts to adapt bone structure and composition to meet physiological loading demands. Experimental ... -
Mechanisms of osteocyte stimulation in osteoporosis
Verbruggen, Stefaan W.; Vaughan, Ted J.; McNamara, Laoise M. (Elsevier, 2016-05-10)Experimental studies have shown that primary osteoporosis' caused by oestrogen deficiency results in localised alterations in bone tissue properties and mineral composition. Additionally, changes to the lacunar-canalicular ... -
Strain amplification in bone mechanobiology: a computational investigation of the in vivo mechanics of osteocytes
Verbruggen, Stefaan W.; Vaughan, Ted J.; McNamara, Laoise M. (The Royal Society Publishing, 2012-06-06)The osteocyte is believed to act as the main sensor of mechanical stimulus in bone, controlling signalling for bone growth and resorption in response to changes in the mechanical demands placed on our bones throughout life. ...