Browsing College of Engineering and Informatics by Author "Pandit, Abhay"
Now showing items 1-12 of 12
-
A Biomaterial Approach to Peripheral Nerve Regeneration: Bridging the Peripheral Nerve Gap and Enhancing Functional Recovery
Daly, William; Yao, Li; Zeugolis, Dimitrios I.; Pandit, Abhay (The Royal Society, 2011-11)Microsurgical techniques for the treatment of large peripheral nerve injuries (such as the gold standard autograft) and its main clinically approved alternative 'hollow nerve guidance conduits (NGCs)' have a number of ... -
DNA Immobilization and Detection on Cellulose Paper using a Surface Grown Cationic Polymer via ATRP
Aied, Ahmed; Zheng, Yu; Pandit, Abhay (American Chemical Society, 2012-02-02)Cationic polymers with various structures have been widely investigated in the areas of medical diagnostics and molecular, biology because of their unique binding properties and capability to interact with biological ... -
Electromechanical properties of dried tendon and isoelectrically focused collagen hydrogels
Abu-Rub, Mohammad; Zeugolis, Dimitrios I.; Pandit, Abhay (Elsevier, 2012-08)Assembling artificial collagenous tissues with structural, functional, and mechanical properties which mimic natural tissues is of vital importance for many tissue engineering applications. While the electro-mechanical ... -
A Fluorescently Labeled, Hyperbranched Polymer Synthesized from DE-ATRP for the Detection of DNA Hybridization
Aied, Ahmed; Glynn, Barry; Cao, Hongliang; Zheng, Yu; Pandit, Abhay; Wang, Wenxin (Royal Society of Chemistry, 2012-01)The early detection of oligonucleotide biomarkers of disease, such as microRNAs, has been established as a fundamental factor in cancer diagnosis. As the levels of these small molecules (microRNAs) in blood have recently ... -
Hyperbranched PEGmethacrylate linear pDMAEMA block copolymer as an efficient non-viral gene delivery vector
Mathew, Asha; Cao, Hongliang; Collin, Estelle; Wang, Wenxin; Pandit, Abhay (Elsevier, 2012-06-02)A unique hyperbranched polymeric system with a linear poly-2-dimethylaminoethyl methacrylate (pDMAEMA) block and a hyperbranched polyethylene glycol methyl ether methacrylate (PEGMEMA) and ethylene dimethacrylate (EGDMA) ... -
Macromolecular crowding meets tissue engineering by self-ssembly: A paradigm shift in regenerative medicine
Satyam, Abhigyan; Kumar, Pramod; Fan, Xingliang; Gorelov, Alexander; Rochev, Yury; Joshi, Lokesh; Peinado, Héctor; Lyden, David; Thomas, Benjamin; Rodriguez, Brian; Raghunath, Michael; Pandit, Abhay; Zeugolis, Dimitrios I. (Wiley, 2014-02-06)Advancements in molecular and cell biology have led to the development of cell-based therapies to treat injured or degenerated tissues. [1] The rationale of this concept is that functional regeneration can be achieved ... -
Mannosylated Polyethyleneimine-Hyaluronan Nanohybrids for Targeted Gene Delivery to Macrophage-Like Cell Lines
Mahor, Sunil; Dash, Biraja C.; O'Connor, Stephen; Pandit, Abhay (American Chemical Society, 2012-05-02)Nonviral gene delivery systems have a number of limitations including low transfection efficiency, specificity, and cytotoxicity, especially when the target cells are macrophages. To address these issues, the hypothesis ... -
The past, present and future in scaffold-based tendon treatments
Lomas, A.J.; Ryan, C.N.M.; Sorushanova, A.; Shologu, N.; Sideri, A.I.; Tsioli, V.; Fthenakis, G.C.; Tzora, A.; Skoufos, I.; Quinlan, Leo R.; Ó Laighin, Gearóid; Mullen, A.M.; Kelly, A.M.; Kearns, J.L.; Biggs, S.; Pandit, Abhay; Zeugolis, Dimitrios I. (Elsevier, 2015-04)Tendon injuries represent a significant clinical burden on healthcare systems worldwide. As the human population ages and the life expectancy increases, tendon injuries will become more prevalent especially among young ... -
Preferential cell response to anisotropic electro-spun fibrous scaffolds under tension-free conditions
Pandit, Abhay; Zeugolis, Dimitrios I. (Springer, 2010-11)Anisotropic alignment of collagen fibres in musculoskeletal tissues is responsible for the resistance to mechanical loading, whilst in cornea is responsible for transparency. Herein, we evaluated the response of tenocytes, ... -
Recovery of cardiac function mediated by MSC and interleukin-10 plasmid functionalised scaffold
Holladay, Carolyn A.; Duffy, Aoife M.; Chen, Xizhe; O'Brien, Timothy; Pandit, Abhay (2011-11)Stem cell transplantation has been suggested as a treatment for myocardial infarction, but clinical studies have yet to demonstrate conclusive, positive effects. This may be related to poor survival of the transplanted ... -
Single Cyclized Molecule Structure from RAFT Homopolymerization of Multi-vinyl Monomers
Zheng, Yu; Newland, Ben; Pandit, Abhay; Wang, Wenxin (2012)We explore a kinetically controlled strategy to suppress the gelation in the homopolymerization of multi-vinyl monomers (MVMs) via RAFT polymerization. We report the generation of 3D single cyclized polymer structures from ... -
Single Cyclized Molecule Versus Single Branched Molecule: A Simple and Efficient 3D "Knot" Polymer Structure for Nonviral Gene Delivery
Newland, Ben; Zheng, Yu; Jin, Yao; Abu-Rub, Mohammad; Cao, Hongliang; Wang, Wenxin; Pandit, Abhay (American Chemical Society, 2012-02-12)The large research effort focused on enhancing nonviral transfection vectors has clearly demonstrated that their macromolecular structure has a significant effect on their transfection efficacy. The 3D branched polymeric ...