Browsing College of Engineering and Informatics by Author "McGarry, J. Patrick"
Now showing items 1-9 of 9
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Cellular contractility and substrate elasticity: a numerical investigation of the actin cytoskeleton and cell adhesion
Ronan, William; Deshpande, Vikram S.; McMeeking, Robert M.; McGarry, J. Patrick (Springer Verlag, 2013-06-18)Numerous experimental studies have established that cells can sense the stiffness of underlying substrates and have quantified the effect of substrate stiffness on stress fibre formation, focal adhesion area, cell traction, ... -
Computational investigation of in situ chondrocyte deformation and actin cytoskeleton remodelling under physiological loading
Dowling, Enda P.; Ronan, William; McGarry, J. Patrick (Elsevier, 2012-12-24)Previous experimental studies have determined local strain fields for both healthy and degenerate cartilage tissue during mechanical loading. However, the biomechanical response of chondrocytes in situ, in particular the ... -
An experimental and computational investigation of the post-yield behaviour of trabecular bone during vertebral device subsidence
Kelly, Nicola; Harrison, Noel M.; McDonnell, Pat F.; McGarry, J. Patrick (Springer-Verlag, 2013)Interbody fusion device subsidence has been reported clinically. An enhanced understanding of the mechanical behaviour of the surrounding bone would allow for accurate predictions of vertebral subsidence. The multiaxial ... -
Experimental and computational investigation of the role of stress fiber contractility in the resistance of osteoblasts to compression
McGarry, J. Patrick; Weafer, Paul; Jarvis, S. P.; Ronan, William (2013)The mechanical behavior of the actin cytoskeleton has previously been investigated using both experimental and computational techniques. However, these investigations have not elucidated the role the cytoskeleton plays in ... -
Experimental and numerical characterisation of the elasto-plastic properties of bovine trabecular bone and a trabecular bone analogue
Kelly, Nicola; McGarry, J. Patrick (2012)The inelastic pressure dependent compressive behaviour of bovine trabecular bone is investigated through experimental and computational analysis. Two loading configurations are implemented, uniaxial and confined compression, ... -
An investigation of the inelastic behaviour of trabecular bone during the press-fit implantation of a tibial component in total knee arthroplasty
Kelly, Nicola; Cawley, DT; Shannon, FJ; McGarry, J. Patrick (Institute of Physics and Engineering in Medicine by Elsevier Ltd., 2013)The stress distribution and plastic deformation of peri-prosthetic trabecular bone during press-fit tibial component implantation in total knee arthroplasty is investigated using experimental and finite element techniques. ... -
Numerical investigation of the active role of the actin cytoskeleton in the compression resistance of cells
Ronan, William; McGarry, J. Patrick (Elsevier ScienceDirect, 2012-06-21)Numerous in-vitro studies have established that cells react to their physical environment and to applied mechanical loading. However, the mechanisms underlying such phenomena are poorly understood. Previous modelling of ... -
On the role of the actin cytoskeleton and nucleus in the biomechanical response of spread cells
Reynolds, Noel H.; Ronan, William; Dowling, Enda P.; McMeeking, Robert M.; McGarry, J. Patrick (Elsevier, 2014-02-11)Micropipette aspiration (MA) has been used extensively in biomechanical investigations of un-adhered cells suspended in media. In the current study, a custom MA system is developed to aspirate substrate adhered spread ... -
Stability enhancement of an atomic force microscope for long-term force measurement including cantilever modification for whole cell deformation
McGarry, J. Patrick; Weafer, Paul; Ronan, William; Nolan, D. R. (2012)Atomic force microscopy (AFM) is widely used in the study of both morphology and mechanical properties of living cells under physiologically relevant conditions. However, quantitative experiments on timescales of minutes ...