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dc.contributor.authorElliott, Marken
dc.date.accessioned2010-11-26T16:02:36Zen
dc.date.available2010-11-26T16:02:36Zen
dc.date.issued2000-10-20en
dc.identifier.citationElliott, M. A., Becker, C., Boucart, Mueller, H. J. (2000). Enhanced GABAA inhibition enhances synchrony coding in human perception. NeuroReport, 11(15), 3403-3407.en
dc.identifier.issn0959-4965en
dc.identifier.urihttp://hdl.handle.net/10379/1462en
dc.description.abstractThe benzodiazepine, lorazepam enhances the efficiency of local, inhibitory GABAA synapses in the cortex, which stabilize postsynaptic, excitatory activity by synchronizing their own discharges at around 40 Hz. Treatment with lorazepam has also been shown to adversely influence detection performance in perceptual tasks, suggesting a role for GABAA-mediated synchronization during visuo-perceptual organization. Consistent with these findings we report that reaction times to target stimuli were slower following lorazepam treatment. However, when targets followed presentation of a synchronized prime, presented within a flickering 40-Hz display matrix, the effects of priming were amplified relative to baseline and control conditions. We conclude that enhanced GABAA-induced inhibition enhances stimulus-evoked synchronization with differential effects upon mechanisms of perceptual segmentation and grouping.en
dc.formatapplication/pdfen
dc.language.isoenen
dc.publisherLippincott Williams & Wilkinsen
dc.subjectPsychologyen
dc.subject40 Hzen
dc.subjectBenzodiazepineen
dc.subjectGABAAen
dc.subjectGroupingen
dc.subjectLorazepamen
dc.subjectPrimingen
dc.subjectSegmentationen
dc.subjectSynchronizationen
dc.subjectVisionen
dc.titleEnhanced GABA-A inhibition enhances synchrony coding in human perceptionen
dc.typeArticleen
dc.local.publishedsourcehttp://journals.lww.com/neuroreport/Fulltext/2000/10200/Enhanced_GABAA_inhibition_enhances_synchrony.27.aspxen
dc.description.peer-reviewedpeer-revieweden
dc.contributor.funderDeutsche Forschungsgemeinschaft project grant SCHR 375/8-1en
dc.contributor.funderEEC Biomed 2 project granten
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