Show simple item record

dc.contributor.authorSamali, Afshinen
dc.contributor.authorSanjeev, Guptaen
dc.contributor.authorNí Chonghaile, Tríonaen
dc.contributor.authorMacDonald, David Cen
dc.contributor.authorSzegezdi, Evaen
dc.date.accessioned2009-04-30T09:10:24Zen
dc.date.available2009-04-30T09:10:24Zen
dc.date.issued2009en
dc.identifier.urihttp://hdl.handle.net/10379/145en
dc.description.abstractThe endoplasmic reticulum (ER) is the main site for protein folding, lipid biosynthesis and calcium storage in the cell. Disturbances of these critical cellular functions lead to ER stress. The ER responds to disturbances in its homeostasis by launching an adaptive signal transduction pathway, known as the unfolded protein response (UPR). The UPR strives to maintain ER function during stress; however, if the stress is not resolved apoptotic responses are activated that involve crosstalk between the ER and mitochondria. In addition, ER stress is also known to induce autophagy to counteract XBP-1 mediated ER expansion and assist in the degradation of unfolded proteins. One family of proteins involved in the regulation of apoptosis is that of Bcl-2. Complex interactions among the three subgroups within the Bcl-2 family (the anti- apoptotic, the multi-domain pro-apoptotic and the BH3-only members) control the signaling events of apoptosis upstream of mitochondrial outer membrane permeabilization. These proteins were found have diverse subcellular locations to aid in the response to varied intrinsic and extrinsic stimuli. Of recent interest is the presence of the Bcl-2 family at the ER. Here, we review the involvement of proteins from each of the three Bcl-2 family subgroups in the maintenance of ER homeostasis and their participation in ER stress signaling transduction pathways.en
dc.formatapplication/pdfen
dc.language.isoenen
dc.publisherAmerican Physiological Societyen
dc.subjectApoptosisen
dc.subjectIre1en
dc.subjectUnfolded Protein Response (UPR)en
dc.subjectStressen
dc.subjectEndoplasmic reticulum (ER)en
dc.subjectBcl-2 familyen
dc.titleBcl-2 family on guard at the ERen
dc.typeArticleen
dc.identifier.doidoi:10.1152/ajpcell.00612.2008en
dc.local.publishedsourceTBCen
nui.item.downloads0


Files in this item

This item appears in the following Collection(s)

Show simple item record