Browsing University of Galway Theses (PhD Theses) by Subject "XBP1"
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Development of a novel companion diagnostic for IRE1α activity and its application to investigate the role of IRE1α in acute myeloid leukaemia cells
(NUI Galway, 2020-08-28)The unfolded protein response (UPR) is an evolutionarily conserved mechanism activated in response to accumulation of unfolded protein (termed ER stress). Activation of the UPR is observed during many physiological processes ... -
Investigation of IRE1/XBP1s pathway and its potential as a therapeutic target in breast cancer
(2015-09-18)X-Box binding protein 1 (XBP1) is an integral component of the unfolded protein response (UPR), a pro-survival mechanism, triggered by the onset of endoplasmic reticulum stress. Activation of the endoplasmic reticulum ...