Browsing University of Galway Theses (PhD Theses) by Subject "Macromolecular crowding"
Now showing items 1-5 of 5
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Biophysical and biochemical tools for cell phenotype maintenance, differentiation and trans-differentiation
(NUI Galway, 2018-02-22)Tendon injuries constitute an unmet clinical need, with 3 to 5 million new incidents occurring annually worldwide. Tissue grafting and biomaterial-based approaches fail to provide environments that are conducive to ... -
Cell sheet technology meets macromolecular crowding: The self-ssembly approach for corneal stromal development
(2015-05-01)Therapeutic strategies based on the principles of tissue engineering by self-assembly put forward the notion that functional regeneration can be achieved by utilising the inherent capacity of cells to create highly ... -
Macromolecular crowding meets tissue engineering by self-assembly
(2015-01-29)Introduction: Advancements in molecular and cell biology have led to the development of tissue engineering by self-assembly. The driving hypothesis of this concept is that replacement, repair and restoration of lost tissue ... -
Macromolecular crowding transforms regenerative medicine by enabling the accelerated development of functional and truly three-dimensional tissue moduli
(NUI Galway, 2020-11-04)Scaffold-free in vitro organogenesis exploits the innate ability of cells to synthesise and deposit their own extracellular matrix to fabricate tissue-like assemblies. Unfortunately, traditional cell-assembled tissue ... -
Replicating and modulating skin fibrosis in vitro: Multi-compartment collagen devices as dual drug delivery vehicles
(NUI Galway, 2022-01-10)Complex pathologies, such as fibrosis, are often not the result of a singular event, but rather the consequence of multiple disruptions in the normal balance between intricately connected organs, tissues and signalling ...