Browsing University of Galway Theses (PhD Theses) by Author "Elliman, Stephen"
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Ablation of FAP+ stromal cells impairs endogenous revascularization during hind limb ischemia
Chao, Joshua (NUI Galway, 2020-05-08)Stromal cells have long been studied for their putative role in maintaining tissue homeostasis, driving tissue remodeling processes during injury, and modulating inflammation by synergizing with immune cells. Studying ... -
Examining the role of a novel stromal cell protein CD362/Syndecan-2 in the breast tumour microenvironment.
Loftus, Paul Gerard (NUI Galway, 2019-09-04)Tumour-associated stromal cells play a key role in initiating and sustaining tumour growth, metastasis, immune control and chemo-resistance. Thus, identifying stromal proteins that contribute to carcinogenesis may open new ... -
Hypoxia activates the PTHrP – Zfp521 – MEF2C pathway to attenuate hypertrophy in mesenchymal stem cell derived cartilage
Browe, David (2016-04-22)The treatment of cartilage defects remains an unmet medical need as the current treatment options are currently sub-optimal as the most common treatment options; microfracture and autologous chondrocyte implantation (ACI) ...