Browsing University of Galway Theses (PhD Theses) by Subject "Chk1"
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Analysis of Saccharomyces cerevisiae Mec1 and Rad9 functions in the DNA Damage Response
(2012-10-01)The maintenance of genome integrity is critical for cell proliferation and survival of all organisms. Central to the DNA Damage Response are signal-transduction pathways, termed DNA damage checkpoints, conserved from ... -
Role of Rad9 cell cycle phosphorylation in the regulation of Chk1 activation
(2012-01-07)DNA damage checkpoints are triggered in response to DNA insults. Once activated, these pathways prevent replication and segregation of the damaged DNA. In addition to cell cycle delays they regulate repair, transcription ...