Browsing University of Galway Theses (PhD Theses) by Subject "Chemistry"
Now showing items 1-20 of 114
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Advances in ruthenium-based light harvesting materials and photocatalysis: From molecular photosensitizers to photoactive frameworks
(NUI Galway, 2022-04-08)The presented manuscript deals with the areas of light harvesting and photocatalysis in solar chemistry. The work presented is divided into several sections, beginning with an introductory chapter on the main topics involved ... -
Amorphous pharmaceuticals and composites
(NUI Galway, 2018-04-27)An attractive, yet challenging approach to overcome poor water solubility is to convert a crystalline Active Pharmaceutical Ingredient (API) into its more soluble amorphous form.1-3 Nevertheless, the use of amorphous drug ... -
Anisotropy resolved multi-dimensional emission spectroscopy (ARMES): a new tool for the quantitative and structural analysis of proteins
(NUI Galway, 2016-03-24)The quantitative and structural analysis of proteins is of great importance in numerous fields (from industrial to academic research). Requirements like ease of analysis, sample handling, robustness, analysis time, the ... -
Anisotropy Resolved Multidimensional Emission Spectroscopy (ARMES) as a tool for biophysical analysis
(NUI Galway, 2021-10)The development of analytical tools for the biophysical analysis of biological samples is an area of tremendous application and potential. In this work the use and efficacy of an analytical methodology, known as anisotropy ... -
Anisotropy resolved multidimensional emission spectroscopy (ARMES) for the analysis and resolution of insulin oligomer emission
(NUI Galway, 2018-11-14)Protein aggregation is one of the biggest challenges affecting the manufacture and safe use of biopharmaceuticals. Despite efforts made to enhance protein stability [1], aggregation still remains a critical factor in ... -
Anisotropy Resolved Multidimensional Emission Spectroscopy (ARMES) for the analysis of Immunoglobulin G (IgG) type proteins
(NUI Galway, 2020-10-02)Immunoglobulin G (IgG) is the main antibody used in the biopharmaceutical industry for therapeutic purposes. Monoclonal antibodies (mAb) are growing in the marked due to its high specificity and safety. Physical and ... -
An autoignition study of hydrogen and natural gas mixtures under gas turbine relevant conditions in a rapid compression machine
(2013-11-14)This study presents an experimental and modelling investigation of the ignition of hydrogen and natural gas mixtures. These mixtures were chosen due to their relevancy to the gas turbine industry. A detailed chemical ... -
The benign synthesis of bioactive heterocycles using photochemistry and hydrogen peroxide with hydrohalic acids
(2016-07-08)Chapter 1 provides a pertinent review of recent photochemical homolytic aromatic substitution (HAS) literature. Photochemical methods for HAS include UV-light and visible light photoredox catalysis. Recently invented methods ... -
Bioelectrochemical films on electrodes for application to biofuel cells
(2012-05-04)This thesis focuses on studies of both enzymatic (EFC) and microbial (MFC) fuel cells. In the enzymatic fuel cell studies, interactions between enzymes, osmium based complexes and redox polymers are characterized ... -
Biofilms on electrodes and crosslinking of bovine pericardium tissue : application to biopower device development and anti-calcification of bioprosthetic valves
(2017-11-24)Advances in the electrical communications between enzymes and electrodes made it possible to the fabrication of new miniaturized implantable power devices. This thesis is devoted to study and improvement of enzyme electrodes ... -
Bioprocess monitoring using Polarised Multidimensional Fluorescence (pMDF) spectroscopy
(NUI Galway, 2022-06-15)Bioprocess monitoring is essential for biopharmaceutical manufacturing as it helps to ensure the required quality of the therapeutic proteins and maximise the productivity of the bioprocess as per Quality-by-Design (QbD) ... -
Biosupramolecular protein tectonics
(NUI Galway, 2021-03-31)Taking a structural biology approach, this thesis describes in-depth investigations into protein bioconjugation (PEGylation), surface recognition (synthetic receptors), and ligand-mediated assembly (crystalline frameworks). ... -
Calixarene-mediated protein assembly
(2014-05-23)Solved the first crystal structure of a protein-calixarene complex (at 1.4 Angstrom resolution). The results provide exact structural information on the amino acid preference of the anionic p-sulfonatocalix[4]arene (sclx4) ... -
Carbohydrates as precursors to macrocyclic and iminosugar frameworks
(2017-09-30)Natural products have been perceived as privileged structures in drug discovery based on their evolutionary experience. Chapter 1, explores previous exploitation of this platform by medicinal chemists to identify some ... -
Carbohydrates in the synthesis of macrocycles and glycoclusters
(NUI Galway, 2019-01-28)This thesis deals with efforts to generate new bioactive organic compounds. The main focus has been on the use of carbohydrate building blocks for synthesis of both macrocyclic compounds and glycoclusters for biological ... -
Characterisation of bovine pericardium and alternative treatments for its application as biomaterial
(NUI Galway, 2020-04-09)Bovine pericardium is an extensively used biomaterial utilised in a wide range of biomedical devices such as bioprosthetic heart valves. The characterisation techniques employed for the analysis of bovine pericardium and ... -
Chemical diversity of some benthic cyanobacteria from French Polynesia and New Caledonia
(NUI Galway, 2020-08-04)Cyanobacteria are often considered proliferative in relation with the global change affecting oceans worldwide and especially in the coral reefs of the Pacific Ocean. The bloom of the cyanobacteria in the Pacific Ocean are ... -
Chemical diversity of zoantharians from the coast of Ecuador in the tropical eastern Pacific
(NUI Galway, 2019-09-18)This thesis describes the isolation and identification of marine natural products from five zoantharian species collected off the Marine Protected Area El Pelado located in Santa Elena, Ecuador. Ecuador is one of the ... -
Combining biological and chemical approaches in marine biodiscovery
(2017-06-13)Marine organisms are prolific producers of novel and structurally interesting metabolites. The identification of marine natural products contributes to many scientific areas including pharmacology, chemical ecology, chemical ... -
Combustion kinetic studies of future transportation fuels and intermediates
(NUI Galway, 2020-10-22)The transportation sector requires an abundant supply of fossil and/or bio-derived fuels, which all produce significant quantities of greenhouse gas (GHG) emissions. The transportation sector is expected to account for ...