Browsing University of Galway Theses (PhD Theses) by Subject "Centre for Chromosome Biology"
Now showing items 1-10 of 10
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Analysis of Saccharomyces cerevisiae Mec1 and Rad9 functions in the DNA Damage Response
(2012-10-01)The maintenance of genome integrity is critical for cell proliferation and survival of all organisms. Central to the DNA Damage Response are signal-transduction pathways, termed DNA damage checkpoints, conserved from ... -
Biochemical and functional characterization of human MSL2
(2013-04-10)DNA in Eukaryotic cells is complexed with histone proteins to form chromatin. This mediates DNA packaging into the nucleus but also facilitates the regulation of all DNA-templated processes, including transcription, ... -
Effects of proteasome inhibition on cisplatin induced DNA damage responses in human cells
(2012-02-07)The proteasome is the main site of protein degradation in human cells, and plays a major role in the regulation of cellular processes including cell cycle progression, DNA repair and the DNA damage response. Proteasome ... -
Functional Analysis of Vertebrate Msl2
(2014-02-12)hMSL2 (Male Specific Lethal 2, human) is a RING finger protein with E3 ubiquitin ligase activity. Although it has been shown to target histone H2B at lysine 34 and p53 at lysine 351, suggesting roles in transcription ... -
hMOF and associated proteins in transcription and cancer
(2013-04-24)The lysine acetyltransferase MOF (males absent on the first) has been associated with transcriptional activation in Drosophila melanogaster. This activation is mediated by its acetylation of histone H4 at lysine 16 ... -
Impacts of DNA damage on the pericentriolar material and centriole duplication
(2015-12-03)The centrosome consists of two barrel-shaped centrioles embedded in a proteinaceous pericentriolar material (PCM), a highly organised scaffold that serves as a platform for proteins that regulate spindle assembly, protein ... -
Nucleolar reorganisation promotes repair of rDNA double strand breaks by homologous recombination throughout the cell cycle.
(2013-12-16)The nucleolus is the largest functional domain within the nucleus and is the site of ribosome biogenesis. It has a distinct structure and houses ribosomal RNA gene (rDNA) transcription, pre-ribosomal RNA (pre-rRNA) processing, ... -
The primary cilium as a regulator of cellular senescence in human fibroblasts
(2014-02-11)Somatic cells senesce in culture after a finite number of divisions, indefinitely arresting their proliferation. Among the major causes of senescence is persistent DNA damage signalling. DNA damage and senescence increase ... -
The RNA-associated splicing-factor p54nrb regulates survival of human cells following UV irradiation
(2013-04)UV radiation causes several forms of DNA damage; the most prominent of these are cyclobutane pyrimidine dimers (CPDs) and 6-4 pyrimidine-photoproducts (6-4 PPs). Nucleotide excision repair (NER) is a repair process that ... -
The roles of centrins/caltractins at the centrosome and in genome maintenance
(2012-06-21)The principal microtubule-organising centre in animal cells, the centrosome, contains centrin, a small, highly-conserved calcium-binding protein that can be found throughout eukaryotes. Several centrin isoforms exist and ...