Browsing University of Galway Theses (PhD Theses) by Subject "Breast Cancer"
Now showing items 1-12 of 12
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Analysis of MiRNA Expression and Biomarker Potential in Common Diseases: Breast Cancer and Obesity
(2012-05-28)The two greatest health concerns worldwide at present are cancer and obesity; both of which continue to rise in incidence and are associated with high morbidity and mortality. Understanding the aetiology and mechanisms of ... -
Current and potential diagnostic modalities in the detection and management of breast cancer
(NUI Galway, 2021-07-06)Global statistics have demonstrated that breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among female patients, accounting for 23 percent of total cancer cases and 14 percent of ... -
Examining the role of a novel stromal cell protein CD362/Syndecan-2 in the breast tumour microenvironment.
(NUI Galway, 2019-09-04)Tumour-associated stromal cells play a key role in initiating and sustaining tumour growth, metastasis, immune control and chemo-resistance. Thus, identifying stromal proteins that contribute to carcinogenesis may open new ... -
Extracellular vesicle encapsulated microRNAs and breast cancer
(NUI Galway, 2023-02-24)Breast cancer is the most prevalent cancer among women worldwide. There is a clear need for earlier detection methods and more personalised treatments. Extracellular vesicle encapsulated microRNA (EV-miR) provide novel ... -
Identification of prognostic targets in breast cancer using immunohistochemical and in situ hybridisation methodologies
(2011-12-16)Advances in our understanding of the molecular mechanisms underlying breast cancer are leading to improvements in its management. Many of the recent gene-based signatures developed for breast cancer have highlighted the ... -
Mesenchymal stem cell mediated delivery of Extracellular Vesicle (EV)-encapsulated microRNAs for the treatment of breast cancer
(NUI Galway, 2020-08-04)Mesenchymal Stem Cells (MSCs) hold the ability to home to the site of the tumour and bypass the host immune system. Extracellular Vesicles (EVs) are thought to be a fingerprint of the parent cell and therefore MSC-EVs ... -
Metastatic breast cancer: Patterns of metastasis and novel biomarkers
(NUI Galway, 2018-05-25)Breast cancer is a heterogeneous disease and is the leading cause of cancer-related deaths among women, with metastatic disease the principle cause of mortality. In recent years great advances have been made in stratifying ... -
MicroRNAs as biomarkers and therapeutics in breast cancer
(2017-05-25)Micro(mi)RNAs have potential as both therapeutics and circulating biomarkers of disease. This study investigates potential breast cancer biomarkers miR-138, miR-504 and miR-379. Furthermore, it investigates the impact that ... -
MicroRNAs for the treatment of breast cancer
(NUI Galway, 2024-01-12)MicroRNA-379 (miR-379) has been reported as a potent tumour suppressor miRNA with data supporting a potential therapeutic function in breast cancer. Despite this, the exact mechanism of action of miR-379 is still ... -
Molecular profiling and genomic substratification to personalise therapeutic decision making in cancer
(NUI Galway, 2022-08-16)Breast cancer management recognises that the unique genetic expression profiles of each cancer enables substratification into clinically and therapeutically distinct molecular subgroups. There are pragmatic ways of ... -
Regulation of cell fate by microRNAs during unfolded protein response and its role in cancer
(NUI Galway, 2018-12-20)The endoplasmic reticulum (EnR) stress is a common phenomenon in various cancers such as breast, colorectal, skin and hepatocellular carcinoma. Several pathophysiological events (e.g., radiation, aneuploidy, oncogenic ... -
The role of genomic data in stratifying patients within predictive models for breast cancer survival outcome
(NUI Galway, 2024-04-15)Genomic instability (GI), defined as an increased tendency for genomic alterations to occur, is a common feature of cancers and is recognised as a “facilitating” hallmark of cancer. Genomic alterations include base ...