Browsing University of Galway Theses (PhD Theses) by Subject "Biochemistry Department"
Now showing items 1-2 of 2
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Roles of DNA polymerase eta and replication protein A (RPA) in undamaged and platinum-treated human cells
(2012-09-28)Platinum-based drugs are widely used in cancer therapy. Bypass of platinum-induced DNA adducts during DNA replication by specialised DNA polymerases may contribute to drug tolerance and tumour cell resistance. Human cells ... -
Site-directed mapping of nucleosome structure and dynamics in vitro
(2013-03-04)The nucleosome core particle is the most basic unit of chromatin packaging. It is composed of an octamer of two each of the histone proteins H2A, H2B, H3 and H4 wrapped in ~147 bp of DNA. Nucleosome positioning and sliding ...