Browsing University of Galway Theses (PhD Theses) by Subject "ATR"
Now showing items 1-4 of 4
-
Analysis of Saccharomyces cerevisiae Mec1 and Rad9 functions in the DNA Damage Response
(2012-10-01)The maintenance of genome integrity is critical for cell proliferation and survival of all organisms. Central to the DNA Damage Response are signal-transduction pathways, termed DNA damage checkpoints, conserved from ... -
ATR mediated regulation of the abscission checkpoint
(NUI Galway, 2018-05-30)Unperturbed mitotic cell division is essential for survival. For cells to complete mitosis, genetic material must be distributed equally between the new cells before the final abscission. Failure to complete chromosome ... -
ATR prevents cells entering mitosis with excess unreplicated DNA and is required for the Abscission Checkpoint
(2014-08-15)Maintaining genome integrity is an essential requirement for cells and a tightly regulated DNA damage response (DDR) is required to maintain viability of the cell and prevent disease. ATM and ATR are key regulators in ... -
Genetic analysis of ATR, a central regulator of genome stability.
(2016-05-11)To protect the DNA against the constant assaults of endogenous and environmental agents, cells have developed conserved signaling pathways, known as the DNA damage response. Such responses are important to maintain genome ...