Browsing University of Galway Theses (PhD Theses) by Subject "Unfolded protein response"

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    • Investigating the role of IRE1α RNase activity in breast cancer 

      McGrath, Eoghan Patrick (NUI Galway, 2018-12-17)
      Metastatic, drug resistant disease poses the greatest threat to the survival of breast cancer patients. Thus, elucidating and targeting mechanisms which govern this phenotype is a primary goal of the breast cancer field. ...

    • The role of IRE1α in the regulation of cytokine production 

      Talty, Aaron (NUI Galway, 2020-04-16)
      Inositol-requiring enzyme 1 (IRE1), a key mediator of the unfolded protein response (UPR), has emerging roles within innate immunity and cancer progression. Here we examine how IRE1 signalling influences the production ...