Browsing University of Galway Theses (PhD Theses) by Subject "TRAIL"
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Cytotoxic drug induced JNK activation is DR5-dependent and vital for apoptosis and provides a new target for MSC-mediated delivery of DR5-specific sTRAIL variants
(2013-03-20)Over the past two decades, cancer research has produced tremendous advances in our understanding of the pathogenesis of cancer. Among the most important of these advances is the realization that apoptosis and the proteins ... -
Decoy Receptors block tumour cell eradication by TRAIL - Molecular engineering of TRAIL to evade decoy receptors
(2012-06-29)Tumour necrosis factor-related apoptosis inducing ligand (TRAIL) is a cytokine expressed by immune cells which selectively eradicates a wide range of cancer cells while leaving normal healthy cells unharmed. TRAIL binds ... -
Identification of decisive molecular interactions regulating resistance to apoptosis in tumour cells
(14-07-04)TRAIL is a member of the TNF family of cytokines which can selectively induce apoptosis in cancerous cells. For this reason recombinant TRAIL is being considered for the treatment of cancer. During their development cancer ... -
Identification of novel drug combinations for haematological malignancies
(2015-01-29)TNF-related apoptosis ligand (TRAIL) is a tumour selective cytokine with potential anti-cancer activity which is currently in clinical trials. Haematological malignancies along with several other cancers have showed varied ... -
Regulators of TRAIL resistance in normal and transformed cells
(2015-05-26)TRAIL is a member of the Tumor Necrosis Factor superfamily which was shown to be able to induce apoptotic cell death in a wide variety of transformed cells, leaving normal, healthy cells unharmed. However, approximately ...