Browsing University of Galway Theses (PhD Theses) by Subject "MicroRNA"
Now showing items 1-9 of 9
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Analysis of MiRNA Expression and Biomarker Potential in Common Diseases: Breast Cancer and Obesity
(2012-05-28)The two greatest health concerns worldwide at present are cancer and obesity; both of which continue to rise in incidence and are associated with high morbidity and mortality. Understanding the aetiology and mechanisms of ... -
Mesenchymal stem cell mediated delivery of Extracellular Vesicle (EV)-encapsulated microRNAs for the treatment of breast cancer
(NUI Galway, 2020-08-04)Mesenchymal Stem Cells (MSCs) hold the ability to home to the site of the tumour and bypass the host immune system. Extracellular Vesicles (EVs) are thought to be a fingerprint of the parent cell and therefore MSC-EVs ... -
MicroRNAs as biomarkers and therapeutics in breast cancer
(2017-05-25)Micro(mi)RNAs have potential as both therapeutics and circulating biomarkers of disease. This study investigates potential breast cancer biomarkers miR-138, miR-504 and miR-379. Furthermore, it investigates the impact that ... -
Molecular mechanisms and tumour heterogeneity in breast cancer
(2014-05-07)MicroRNAs play a critical role in regulation of gene expression and are known to be dysregulated in breast cancer. The aim of this study was investigate four microRNAs miR-875-5p, miR-339-5p, miR-10a and miR-379 which were ... -
Novel mechanisms for neoadjuvant chemotherapeutic response monitoring in breast cancer
(2016-11-25)Breast cancer is the most frequently diagnosed female malignancy worldwide, causing the majority of cancer-related deaths amongst women. While the management of this disease has transformed dramatically in recent years, ... -
The prognostic value of protein and microRNA biomarkers in breast cancer and their role in tumour progression
(2014-05-14)Identification of biomarkers has proven valuable in prognostication and treatment stratification of individual cases of breast cancer. microRNAs, short non-coding RNA molecules which negatively regulate translation of mRNA, ... -
Regulation of cell fate by microRNAs during unfolded protein response and its role in cancer
(NUI Galway, 2018-12-20)The endoplasmic reticulum (EnR) stress is a common phenomenon in various cancers such as breast, colorectal, skin and hepatocellular carcinoma. Several pathophysiological events (e.g., radiation, aneuploidy, oncogenic ... -
Role of MicroRNAs and unfolded protein response in breast cancer
(2017-11-24)Stressful conditions of the tumour microenvironment which overwhelm the folding capacity of the endoplasmic reticulum (EnR) activate an evolutionary conserved signalling pathway known as the unfolded protein response (UPR). ... -
The roles of microRNAs in human mesenchymal stem cell adipogenesis
(2012-05-28)The current epidemic of obesity has resulted in a renewed interest in the developmental origins of adipose tissue. Adipose tissue is formed from mesenchymal stem cells (MSCs) in a process known as adipogenesis. MicroRNAs ...