Browsing University of Galway Theses (PhD Theses) by Subject "MSCs"
Now showing items 1-4 of 4
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In vitro, pre-clinical and commercial evaluation of a novel xeno- and serum-free culture system for production of human bone marrow derived mesenchymal stem cells for bone regeneration
(2016-10-21)The therapeutic potential of mesenchymal stem cells (MSCs) is recognised in treating a wide range of debilitating diseases. For clinical-scale manufacturing, serum-free and xenogenic-free media formulations have been ... -
The mechanical environment of the stem cell niche in bone marrow
(2014-06-13)Understanding how bone marrow mesenchymal stem cells (MSCs) contribute to new bone formation and remodelling in vivo is of principal importance for informing the development of effective bone tissue engineering strategies ... -
Therapies for acute respiratory distress syndrome: determination of the mechanisms of action of hypercapnia and the therapeutic efficacy of mesenchymal stromal cells
(2016-09-20)Rationale: Acute Respiratory Distress Syndrome (ARDS) causes severe respiratory failure and is associated with high mortality. Pharmacological therapies are non-existent and supportive ventilation treatments are limited. ... -
Understanding the Mechanisms of Action of Hypercapnic Acidosis and the Therapeutic Potential of Human Mesenchymal Stromal Cells in Diminishing Inflammation and Enhancing Repair in Acute Respiratory Distress Syndrome.
(2013-09-30)Acute respiratory distress syndrome (ARDS) is a term used to describe severe lung injury characterised by uncontrolled inflammatory response and resultant damage to endothelial and epithelial layers leading to eventual ...