Browsing University of Galway Theses (PhD Theses) by Author "Egan, Laurence"
Now showing items 1-3 of 3
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Analysis and interpretation of epigenomic patterns in colonic epithelia
Barnicle, Alan (2015-12-18)The methylation of cytosine nucleotides at the 5' position of DNA is a crucial epigenetic mechanism for the control of gene expression. Epigenome-wide associated studies have demonstrated that specific methylome patterns ... -
Cellular interactions in the tumour microenvironment during inflammation-associated carcinogenesis
O'Malley, Grace (2017-11-30)The colon tumour microenvironment is highly stromal in composition and a greater stromal cell density correlates with a poor prognosis for patients. The majority of these stromal cells are of mesenchymal origin (MSCs) and ... -
The effects of anti-TNFα antibody therapy on peripheral blood mononuclear cells in patients with inflammatory bowel disease
Slevin, Stephanie (2015-09-30)Monocytes, recently classified as CD14++CD16- (classical), CD14++CD16+ (intermediate) and CD14dimCD16++ (non-classical) are considered to play a role in the pathogenesis of inflammatory bowel diseases (IBD). Anti-tumor ...