Browsing University of Galway Theses (PhD Theses) by Author "Barry, Frank"
Now showing items 1-9 of 9
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Biomaterial scaffolds and genetically modified stem cells - An Investigation of their potential in bone repair
Sadasivan, Saraswathi (2017-10-10)The task of repairing large sections of bone tissue lost due to major trauma or pathology poses a significant challenge in orthopedic healthcare. The medical intervention often resorted to consists of a combination of ... -
Evaluation of human induced pluripotent stem cell-based cellular models for pathological investigation of genetic skeletal diseases
Xu, Maojia (NUI Galway, 2019-02-15)The uniqueness of stem cells endows them with the capacity to be used as a valuable tool in the field of pathology, particularly the one from patients. Patient-specific cellular model can be generated by deriving donor-specific ... -
Glycosaminoglycan Dependent Isolation of Mesenchymal Chondroprogenitor Populations from Human Bone Marrow
O'Sullivan, Janice (2013-01-24)Osteoarthritis (OA) is a chronic disease of joints characterised by progressive destruction of articular cartilage resulting in painful, limited joint movement. Cartilage has a limited ability to self-repair due to low ... -
Hypoxia activates the PTHrP – Zfp521 – MEF2C pathway to attenuate hypertrophy in mesenchymal stem cell derived cartilage
Browe, David (2016-04-22)The treatment of cartilage defects remains an unmet medical need as the current treatment options are currently sub-optimal as the most common treatment options; microfracture and autologous chondrocyte implantation (ACI) ... -
Immunomodulation in mesenchymal stem cell therapy for osteoarthritis: mechanistic insights on the role of cell death and engraftment
Mancuso, Patrizio (NUI Galway, 2018-11-02)Osteoarthritis (OA) is a degenerative pathology of the articular cartilage causing chronic pain and disability in millions of individuals. In OA synovia, resident macrophages and infiltrated lymphocytes contribute to the ... -
Media matters: Impact of expansion media on the phenotype of mesenchymal stromal cells
Fitzgerald, Joan (NUI Galway, 2023-03-02)Despite a long history of investigation and sustained efforts in clinical testing with large numbers of clinical trials being initiated, the number of market authorisations for mesenchymal stromal cell (MSC) therapies ... -
Processing the scientific literature for protein relations (for myocardial infarction) and validation of hypothetical relations through experimental results
Halder, Arindam (NUI Galway, 2020-02-28)The last decade has been characterized by a deluge of published scientific literature as well as data generation by biological experiments. The major impediment for the research community to unlock the knowledge contained ... -
Semantic modelling of protein-protein interactions, their prediction and evaluation
Kazemzadeh, Laleh (2018-02-23)The amount of biomedical data produced by DNA-sequencing, by curated knowledge on disease mechanisms and treatments, by results from biochemical and pharmaceutical research and by many other data generation studies is ... -
Targeted Tissue Engineering: Enhancing Mesenchymal Stem Cell Localisation and Therapeutic Support for Cartilage Repair
Bulman, Sarah Elizabeth (2014-01-06)Osteoarthritis, the most common form of arthritis, is a progressive degenerative disease of cartilage and the synovial joint. Since cartilage is an avascular tissue with a limited capacity for self-repair, mesenchymal ...