Browsing University of Galway Theses (PhD Theses) by Title
Now showing items 755-774 of 2238
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Exosome-encapsulated microRNAs as circulating biomarkers for breast cancer
(2016-06-15)Breast cancer is a heterogeneous group of diseases survival from which depends on stage at diagnosis. The development of blood-based biomarkers which may facilitate earlier detection and possibly subtype delineation remains ... -
Expansion and augmentation of social marketing theory and practice with systems science and mechanism, action, structure (MAS) theory to explore dynamic complexity and leverage points pertinent to the Galway cycling system
(NUI Galway, 2019-05-08)Social marketing is confronted by serious challenges of both endogenous and exogenous character. If these challenges are not properly addressed, social marketing risks entering into a deep, intrinsic and ontological crisis. ... -
The experience of providing care to those dying with dementia: family carers' perspectives
(NUI Galway, 2019-02-15)It is widely reported that carers who provide care for a family member with dementia endure physical and psychological burdens. Not only do they fulfil an important role for the person with dementia but also for the wider ... -
The experiences and implications of living with a BRCA1/2 alteration: Establishing the evidence base
(NUI Galway, 2023-03-23)Background BRCA1/2 alterations refer to a pathogenic variant in BRCA1 and BRCA2 genes. Having a BRCA1/2 alteration leads to a significant increase in lifetime risk of developing certain cancers, namely melanomas, ... -
Experimental and computational analysis of the mechanical behavior of poly(lactic-co-glycolic acid) during degradation for medical implant applications
(2016-01-25)Biodegradable polymers such as PLGA have been used in a wide range of biomedical applications due to their hydrolytic degradation and biocompatibility. The mechanical performance of biodegradable polymers during degradation ... -
Experimental and computational investigation into mechanobiology of osteocytes
(2014-10-31)Osteocytes are terminally differentiated bone cells, derived from osteoblasts, which comprise over 90% of the cells in mature bone tissue and are known to be highly sensitive to extracellular mechanical cues. The effect ... -
An experimental and computational investigation into procedural complications relating to transcatheter aortic heart valves
(NUI Galway, 2018-02-20)Although transcatheter aortic valves are widely used for treatment of high to medium risk patients with severe aortic stenosis, there are still many associated procedural complications. In particular, new on-set conductance ... -
Experimental and computational investigation of adhesion junction mechanosensation
(2017-02-28)Bone is an adaptive tissue that remodels in response to the mechanical loads placed upon it during normal daily activity. This remodelling process is vital to maintaining the mechanical integrity, mass and structure of ... -
Experimental and computational investigation of atherosclerotic plaque biomechanics
(NUI Galway, 2019-11-22)The overall objective of this thesis is to provide new insights into the composition and biomechanical behaviour of atherosclerotic plaque. Experimental and computational analysis techniques are developed to investigate ... -
Experimental and computational investigation of the active force generation of cells subjected to static and dynamic loading
(2016-05-13)The development of a mechanistic understanding of the processes by which cells sense and actively respond to the mechanical environment would represent a significant advance in the fields of biomechanics and tissue ... -
An experimental and computational investigation of the corrosion behaviour and mechanical performance of a bioabsorbable medical grade magnesium alloy
(NUI Galway, 2023-05-29)Magnesium-based medical implants have the potential to overcome several complications that arise with permanent metallic implants. Magnesium-based implants are biodegradable such that they can undergo absorption once ... -
An experimental and computational investigation of the high temperature behaviour of MarBN steel with application to effects of manufacturing
(NUI Galway, 2018-10-30)The key step for next generation power plants is the development of advanced materials capable of achieving high flexibility and efficiency at increased steam temperatures and pressures. Such operating conditions will cause ... -
Experimental and computational investigation of the impact of distorted stent expansion on the performance of transcatheter aortic valve replacements
(2014-12-22)Patients with calcific aortic valve stenosis present with calcium deposits on the aortic valve, which can result in non-circular and distorted expansion of self-expanding Transcatheter Aortic Valve Replacements. The effect ... -
An Experimental and Computational Investigation of the Inelastic Behaviour of Trabecular Bone
(2012-09-28)Achieving sufficient initial implant stability is of paramount importance for orthopaedic device longevity. In order to improve the design of orthopaedic devices it is essential to gain a better understanding of the ... -
An experimental and computational investigation of the mechanics of degradation in polymer bioresorbable scaffolds
(NUI Galway, 2023-10-03)Drug-eluting stents (DES) have established themselves as the gold-standard in treating arterial blockages, with over 1.3 million stent procedures carried out across Europe in coronary vessels alone. However, these permanent ... -
An experimental and computational investigation on the biomechanics of polymer-covered self-expanding stents
(NUI Galway, 2021-07-09)Nitinol self-expanding stents are commonly used to treat peripheral artery disease. However, the femoropopliteal artery presents a challenging environment for stent placement, where large arterial deformations occur many ... -
Experimental and finite element investigations of the serviceability behaviour of CLT floors
(NUI Galway, 2020-02-06)Global environmental concerns with regard to sustaining our growing population is prompting the building community worldwide to increase urban density, while using optimised and sustainable resources. The traditional ... -
Experimental and modelling studies of natural gas and gasoline surrogate blends
(NUI Galway, 2023-03-09)Combustors rely heavily on fossil and/or bio-derived fuels that all produce significant quantities of greenhouse gas (GHG) emissions. Hence, the successful development of advanced combustors requires predictive chemical ... -
An experimental and modelling study of selected oxygenated biofuels
(2014-10-13)Detailed chemical kinetic models are useful tools for the development of more efficient combustion systems. These models require validation of the elementary kinetics used in order for them to be accurate and reliable. ... -
An experimental and modelling study of the combustion of oxygenated hydrocarbons
(2014-03-19)A chemical kinetic mechanism for the combustion of acetone has been developed and compared with a range of experimental data from the literature and with species concentration profiles measured in this study in the Princeton ...