Browsing University of Galway Theses (PhD Theses) by Title
Now showing items 223-242 of 2213
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CDC7 kinase regulates DNA replication fork processing and its inhibition is modulated by PTBP1
(NUI Galway, 2022-09-21)CDC7 is an essential serine/threonine kinase that regulates the initiation of DNA replication by phosphorylating several sites of the MCM helicase complex. Several inhibitors of CDC7 are available that reduce cell proliferation ... -
Cell cycle regulation of centromere assembly in Drosophila male meiosis
(NUI Galway, 2018-03-16)Centromeres are chromosomal sites required for faithful chromosome segregation. CENP-A is the histone H3 variant that demarcates centromeres from bulk chromatin. Errors in centromere assembly result in segregation defects ... -
Cell Cycle-dependence of cisplatin-and carboplatin-induced dna damage
(2011-09-30)Platinum-based chemotherapeutic drugs such as cisplatin and carboplatin induce intra- and interstrand crosslinks, resulting in replication arrest, and cell death. Translesion synthesis by DNA polymerase eta, is one way in ... -
Cell fate commitment during nervous system establishment: from stem cells to neurons
(NUI Galway, 2020-07-06)Members of the early-branching metazoan phylum of Cnidaria are well-recognized as a sister group to bilaterians making them an ideal candidate to study the evolution of the eumetazoan nervous system. I began to unravel the ... -
Cell sheet technology meets macromolecular crowding: The self-ssembly approach for corneal stromal development
(2015-05-01)Therapeutic strategies based on the principles of tissue engineering by self-assembly put forward the notion that functional regeneration can be achieved by utilising the inherent capacity of cells to create highly ... -
Cell wall immunocytochemistry and histology of hemiparasitism in Rhinanthus minor L. and Odontites vernus (Bellardi) Dumort: interactions at haustorial interfaces and implications for grassland biodiversity
(2013-11-21)Parasitic plants develop specialised grafting organs called haustoria to attach to and infiltrate host plant organs to access nutrients. The outcome of the parasitic process is largely determined where cell walls of the ... -
A cell-based study exploring novel therapeutic approaches to target cell stress and cell death pathways in paediatric cancers
(NUI Galway, 2020-08-17)Paediatric cancer is the leading cause of death by disease in children. High mortality rates and long-term effects of conventional treatments suggest an urgent need for basic and translational research to allow treatment ... -
Cellular interactions in the tumour microenvironment during inflammation-associated carcinogenesis
(2017-11-30)The colon tumour microenvironment is highly stromal in composition and a greater stromal cell density correlates with a poor prognosis for patients. The majority of these stromal cells are of mesenchymal origin (MSCs) and ... -
Cellular response to stress: role of autophagy and cell death in caspase-9 deficient cells
(2017-10-31)Chronic or unresolved stress can lead to cell death, and induction of apoptosis is crucial when the cellular adaptive mechanisms are not able to resolve persistent stress. Malfunction of the apoptotic process caused by ... -
Cellular responses to endoplasmic reticulum stress: Role of autophagy and cell death
(2014-12-03)This PhD thesis describes cellular responses to the induction of endoplasmic reticulum (ER) stress, focusing on the role of autophagy and cell death. Pro-survival role of unfolded protein response (UPR) is analysed by ... -
The centrality of the Galway hooker to dwelling in the island and coastal communities of south west Conamara
(NUI Galway, 2019-11-30)Abstract This research explores the relational nature of the Galway hooker, a traditional carvel-built wooden sail-boat described by Scott (2004) as “The Workhorse of Galway Bay” (Scott, 2004, p.22). It focuses on the ... -
Centriolar and ciliary responses to DNA damage
(2012-09-26)Centrosome duplication is tightly controlled and takes place only once every cell cycle. In recent years more light has been shed on the mechanism of centrosome duplication, with key players being identified and characterised. ... -
Centrobin functions in centriole duplication, primary ciliogenesis and genome maintenance
(2018-03-06)The centrosome is composed of numerous proteins that make up its core structure. Other proteins also transiently localise and interact with centrosomal proteins for functional modulation. Centrobin, one of the core centrosomal ... -
Centromere function in asymmetrically dividing Drosophila germline stem cells
(NUI Galway, 2023-03-28)Germline stem cells (GSCs) undergo asymmetric cell division (ACD) to give rise to one stem cell residing in the niche and one differentiating daughter cell. The daughter cell subsequently divides through mitosis and meiosis ... -
Centrosome cohesion: functions of C-NAP1
(2016-01-07)Double stranded DNA encodes the genetic material of the cell. Replication and segregation cycles are regulated in order to maintain the integrity of the DNA sequence from one cell cycle to the next. Detection of lesions ... -
Cerebral palsy in the West of Ireland and the application of the international criteria for the identification of acute intrapartum hypoxia: a cohort study.
(2012-05-09)Abstract Background Cerebral palsy is one of the most severe disabilities in childhood and occurs in 1-3 per 1,000 live births in Europe. This epidemiological study looked at a cohort of children with cerebral palsy to ... -
Cervical lymphadenopathy in lung cancer
(NUI Galway, 2021-09-18)Overall, in the thesis we showed that cervical lymphadenopathy is frequently present in patients with lung cancer and mediastinal lymphadenopathy on CT to a degree that justifies screening for it routinely. We have shown ... -
‘Cé leis í?’ Determining the legal position of the ‘Surrogate’ in a surrogacy relationship through the Reproductive Justice Framework: A proposed model for Ireland.
(NUI Galway, 2019-05-29)This thesis asks the question: Cé leis í? (Who is she?) This question refers to the uniquely Irish kinship structure which recognises complex filiation structures. Similarly, advances in assisted human reproduction which ... -
Chain transfer to solvent in the radical polymerization of acrylamide monomers, controlled/living radical polymerizations, including in supercritical carbon dioxide and preparation of carbon dioxide responsive micelles
(2014-12-11)Chapter 1 provides a general introduction to radical polymerization, including chain transfer, and controlled/living radical polymerization. A review of the literature since 2009 on heterogeneous controlled/living radical ... -
Challenging assumptions of vulnerability: the significance of gender in the work, lives and identities of women human rights defenders
(2018-02-16)In 1998, the United Nations General Assembly adopted the Declaration on the Right and Responsibility of Individuals, Groups and Organs of Society to Promote and Protect Universally Recognised Human Rights and Fundamental ...