Browsing University of Galway Theses (PhD Theses) by Title
Now showing items 173-192 of 2242
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Biofortification for better nutrition: developing and delivering crops with more impact
(NUI Galway, 2020-05-06)Background: Globally, around three billion people have inadequate diets and are often malnourished. Biofortification, a nutrition-sensitive approach that aims to increase the nutritional density of staple crops, has great ... -
Biogas clean-up using a novel hollow fibre membrane bioreactor for end-use applications
(NUI Galway, 2022-04-06)The aim of this research was to develop a novel hollow fibre membrane bioreactor (HFMB) that can be used for H2S laden waste gas treatment and biogas desulfurization. In addition, the aim was to utilize the HFMB for ... -
A bioinformatic approach to the genetics, human cell models and animal models of autism spectrum disorder
(NUI Galway, 2021-09-17)Autism Spectrum Disorder (ASD) is a group of complex neurodevelopmental disorders with diverse clinical manifestations and symptoms. In the last 10 years, there have been significant advances in understanding the genetic ... -
Bioinspired micropatterned adhesive surfaces for medical applications: a numerical investigation of fibrillar adhesives and swellable microneedle arrays
(NUI Galway, 2024-03-21)Traditional sutures and tissue adhesives can cause adverse effects, inflicting additional damage to the tissue, resulting in toxic chemical residues, and increasing the risk of infection. Bioinspired adhesives have ... -
Biological and chemical analysis of azaspiracids and amphidinols originating from dinoflagellate strains associated to Irish waters
(NUI Galway, 2024-04-15)Microalgae have the potential to produce biologically active metabolites which can be toxic, affect our fisheries and endanger food safety. Due to their active nature these toxins can also have therapeutic benefits when ... -
A biological and pharmacological investigation of the unfolded protein response in models of breast cancer
(NUI Galway, 2020-11-20)Breast cancer is the most common malignancy in women worldwide. At the molecular level, breast cancer is a heterogeneous disease. For example, the claudin low subtype of breast cancer is characterised by epithelial-mesenchymal ... -
Biological characterization of a human mesenchymal stromal cell product
(2016-07-21)The translation of stem cell research into a therapeutic setting presents with it many scientific, logistic, financial and regulatory challenges for academic scientists. This thesis identifies some key areas that one must ... -
The biology of the slug-killing Tetanocera elata (Diptera: Sciomyzidae) and its potential as a biological control agent for pestiferous slugs
(15-02-05)Laboratory experiments were carried out to determine the effects of controlled temperatures (14oC, 17oC, 20oC, 23oC, and 26oC) and ambient outdoor and laboratory temperatures on the development and predation capacity of ... -
Biomaterial scaffolds and genetically modified stem cells - An Investigation of their potential in bone repair
(2017-10-10)The task of repairing large sections of bone tissue lost due to major trauma or pathology poses a significant challenge in orthopedic healthcare. The medical intervention often resorted to consists of a combination of ... -
A Biomaterials Approach for an Ex-Vivo Multiple Sclerosis Model of Inflammatory Demyelination
(2013-10-03)Multiple sclerosis (MS) is characterised by the presence of inflammatory demyelinating foci throughout the brain and spinal cord, accompanied by axonal and neuronal damage. Although inflammatory processes are thought to ... -
Biomaterials approach for targeted therapeutics delivery in inflammatory bowel disease
(NUI Galway, 2021-01-25)Pathogenesis of inflammatory bowel diseases (IBD) is associated with continuous episodes of diffusive gut epithelial inflammation and dysregulated mucosal immune response. IBD (with major forms Crohn’s and ulcerative ... -
A biomaterials approach to peripheral nerve repair
(2014-04-09)Peripheral nerve injuries are a major clinical problem which currently affect over one million people worldwide. Transection injuries caused by workplace and home injuries, road traffic accidents and by intentional harm ... -
Biomimetic nano-biomaterials for bone repair and regeneration
(2017-02-24)Currently, over 1.7 billion people suffer from a musculoskeletal disorder; over 200 million operations take place annually; and in excess of 1 million new clinical cases are reported per year. Further, the annual healthcare ... -
Biophysical and biochemical microenvironmental cues for tenogenic phenotype maintenance, differentiation and trans-differentiation in vitro
(NUI Galway, 2019-07-19)Tendon injuries affect tens of millions of people worldwide each year and as the average lifespan increases their occurrence also increases, Achilles rupture rates alone have increased by ≈ 1000% in the last 40 years. ... -
Biophysical and biochemical tools for cell phenotype maintenance, differentiation and trans-differentiation
(NUI Galway, 2018-02-22)Tendon injuries constitute an unmet clinical need, with 3 to 5 million new incidents occurring annually worldwide. Tissue grafting and biomaterial-based approaches fail to provide environments that are conducive to ... -
Bioprocess monitoring using Polarised Multidimensional Fluorescence (pMDF) spectroscopy
(NUI Galway, 2022-06-15)Bioprocess monitoring is essential for biopharmaceutical manufacturing as it helps to ensure the required quality of the therapeutic proteins and maximise the productivity of the bioprocess as per Quality-by-Design (QbD) ... -
Biosafety assessment during anaerobic co-digestion of food waste and pig manure
(NUI Galway, 2022-10-11)Antimicrobial resistance (AMR) spreading has been a public concern as it increases the mortality of infection, and some biowastes (such as pig manure, food waste and municipal waste sludges) have been reported as hotspots ... -
Biosupramolecular protein tectonics
(NUI Galway, 2021-03-31)Taking a structural biology approach, this thesis describes in-depth investigations into protein bioconjugation (PEGylation), surface recognition (synthetic receptors), and ligand-mediated assembly (crystalline frameworks). ... -
Blood biomarker monitoring in professional soccer: Longitudinal analysis of inflammation in English Premier League players
(NUI Galway, 2021-09-06)The high intensity demands of elite soccer predispose players to recurrent episodes of acute inflammation, and during periods of frequent match play recovery time may not be adequate for the resolution of the inflammatory ... -
Body and Soul: Turning Turk in Early Modern Barbary captivity narratives
(2016-12-20)This thesis focuses on early modern Barbary captivity narratives which describe Christian encounters with the Islamic world, and gives particular attention to questions of sexuality and gender. From the short fledgling ...