Browsing University of Galway Theses (PhD Theses) by Title
Now showing items 1177-1196 of 2244
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Investigation of the central serotonergic system in the olfactory bulbectomized rat model of depression
(2017-11-10)Depression is a devastating heterogeneous disease that has a high lifetime prevalence. Despite over 50 years of research, the aetiology of depression is still largely undetermined but the improper functioning of the central ... -
An investigation of the contribution of centrosomal genes to schizophrenia and cognitive function
(NUI Galway, 2020-03-11)The centrosome is the key microtubule organising centre of animal somatic cells. Centrosomes play a crucial role in brain development, influencing cell shape, polarity, motility, and division. The older of the two barrel-shaped ... -
An investigation of the effects of thermal and nonthermal processing methods on Polyacetylenes from Apiaceae
(2012)Polyacetylenes are a group of phytochemicals that have attracted significant interest in recent years due to their range of potential health-promoting bioactivities however, little is known about the effects of food ... -
Investigation of the genetic basis of schizophrenia and cognitive function
(NUI Galway, 2019-01-25)Schizophrenia (SZ) is a chronic psychiatric disorder affecting approximately 1% of the population. Symptoms range from delusional thoughts and hallucinations to anhedonia and social withdrawal. Affected individuals also ... -
An investigation of the genetic contribution to cognitive resilience in healthy ageing
(NUI Galway, 2021-07)Cognitive decline is one of the most feared aspects of ageing leading to major health and social issues. Non-pathological or age-related cognitive decline leads to increased challenges in completing tasks that require ... -
An investigation of the immunometabolic interactions of obesity
(2013-09-04)Human monocytes are classified as classical, intermediate and non-classical according to their surface expression of CD14 and CD16. They also represent precursors to atherogenic foam cells and macrophages in metabolically ... -
Investigation of the mechanisms of repair following Ventilator Induced Lung Injury and the potential for Mesenchymal Stem Cells to enhance the repair process
(2012-02-10)Introduction: ARDS is a syndrome of acute respiratory failure that presents with progressive arterial hypoxemia, dyspnea, and a marked increase in the work of breathing. Virtually all patients with ARDS receive mechanical ... -
An investigation of the relationship between international law, international politics and the state using Syria as a case study
(NUI Galway, 2018-11-20)The thesis investigates the relationship between international law, international politics and the state using Syria as a case study. Syria was chosen because it has historically been the site of regional and international ... -
An investigation of the role of body-worn inertial sensing in the analysis of elite swimming performance
(2017-09-29)Swimming is a technically demanding sport that requires ongoing quantitative assessment in order to monitor technical progression and improvements in performance. Traditional methods of monitoring a swimmer’s technique ... -
Investigation of the role of mesenchymal stromal cells in modulating macrophage phenotype and function in the colorectal tumour microenvironment
(NUI Galway, 2022-06-28)Colorectal cancer (CRC) is the third most commonly occurring cancer. While there have been improvements in treatment options for patients, it remains the second leading cause of cancer-related deaths worldwide. CRC develops ... -
Investigation of the role of nuclear factor kappa-B in mediating the effects of hypercapnic acidosis and mesenchymal stem cells in ventilation induced lung injury
(NUI Galway, 2016-11-08)Introduction: ARDS is a syndrome of acute respiratory failure that presents with progressive arterial hypoxemia, dyspnea, and a marked increase in the work of breathing. Mechanical ventilation is necessary to support life ... -
An investigation of the role of the hypersialylated myeloma cell surface in facilitating evasion of natural killer cell-mediated immunosurveillance
(NUI Galway, 2021-12-30)Abnormal glycosylation is a hallmark of cancer, and hypersialylation in particular has been shown to facilitate abnormal cell trafficking and drug resistance in many cancers, including Multiple Myeloma (MM) - a currently ... -
Investigation of the Role of the NF-kB Pathway in Mediating the Effects of Hypercapnic Acidosis in Prolonged Systemic Sepsis and Ventilation Induced Acute Lung Injury
(2012-11)Background: Lung protective ventilation is integral to the management of ARDS. The resulting respiratory acidosis [HCA], termed 'permissive hypercapnia', is protective in diverse non-septic acute lung injury [ALI] models, ... -
Investigation of the structure and function of the metal transporter CzrB from Thermus thermophilus and the molecular chaperone trigger factor from Psychrobacter frigidicola by X-ray crystallography
(2014-09-26)A crystallographic approach was taken to investigate the structure and function of two proteins of interest previously isolated in our research group and identified as having potential application in improving the production ... -
Investigation of the therapeutic potential of mesenchymal stem/stromal cells in preclinical models of systemic sepsis
(NUI Galway, 2020-10-29)Introduction: Sepsis is a syndrome of life-threatening physiologic, pathologic, and biochemical abnormalities resulting from infection 1. The host immune response, specifically the loss of immune homeostasis induced by ... -
An investigation of the viscoelastic and mechano-sorptive creep behaviour of reinforced timber elements
(2016-12-15)The reinforcement of timber using fibre reinforced polymer (FRP) rods or plates is widely accepted as an effective method of increasing the strength and stiffness of members. Across Europe, this technology has been used, ... -
Investigation of transmission of human respiratory pathogens using whole genome sequencing
(NUI Galway, 2023-06-20)This doctoral thesis explores the role of whole genome sequencing in the investigation of transmission of human respiratory pathogens. It is a “PhD thesis by publication” which consists primarily of three published ... -
Investigation of various ligand design approaches and synthesis of diverse heterocyclic bioactive compounds
(NUI Galway, 2019-09-27)Structure-based design and ligand-based design are one of the most common approaches used to develop new inhibitors against druggable protein targets in various human disorders. Mcl-1 is a protein belongs to Bcl-2 family ... -
An investigation on the use of sensory electrical stimulation as a cueing therapy to ameliorate on-state freezing of gait in people with Parkinson's Disease
(NUI Galway, 2021-05-04)People with Parkinson’s (PwP) currently face a significant challenge in managing on-state Freezing of Gait (FoG). While auditory and visual cueing therapies have been shown to ameliorate on-state FoG, studies often show ... -
Investigations into assimilating high-frequency radar data into a three-dimensional hydrodynamic model of a wind-dominated coastal water body
(2015-10)Accurate forecasting of surface currents in coastal waters is of great importance for operations such as search and rescue operations and marine energy extraction. Numerical models and measurements are two powerful ...