Browsing University of Galway Theses (PhD Theses) by Title
Now showing items 1164-1183 of 2242
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Investigation of intron coevolution and the autoimmune potential of alternative splicing
(2016-07-20)Introns are non-coding intergenic sequences that are routinely excised from nascent pre-mRNA transcripts by a process known as splicing. Although they do not contribute directly to the protein-coding sequences of genes, ... -
Investigation of IRE1/XBP1s pathway and its potential as a therapeutic target in breast cancer
(2015-09-18)X-Box binding protein 1 (XBP1) is an integral component of the unfolded protein response (UPR), a pro-survival mechanism, triggered by the onset of endoplasmic reticulum stress. Activation of the endoplasmic reticulum ... -
Investigation of metallacarboranes as unexpected therapeutics against triple-negative breast cancer cells
(NUI Galway, 2023-10-03)Metallacarboranes have been shown to have very promising properties for biomedical applications, with some derivatives having already shown good results in a number of cancer subtypes. The ability to self-aggregate, ... -
The investigation of methylmagnesium chloride as a non-nucleophilic base
(NUI Galway, 2018-11-30)The use of methylmagnesium chloride (MeMgCl) as a non-nucleophilic base is explored in this thesis. Grignard reagents react in nucleophilic addition reactions with nitriles yielding a ketone upon work-up, but in the ... -
Investigation of microbial community structure and function underpinning grass and food waste anaerobic digestion
(2016-08-18)Anaerobic digestion (AD) of feedstocks, such as grass and food waste, presents a sustainable and cost efficient technology for the generation of bioenergy and value added products. However, to fully optimize the process, ... -
An investigation of mucus plugging in severe asthma
(NUI Galway, 2018-05-16)The classic pathologic finding in patients with fatal asthma is of markedly hyperinflated lungs. This hyperinflation is the consequence of widespread plugging of the segmental and sub-segmental airways. In contrast to fatal ... -
An investigation of neuroanatomical contributions to cognitive deficits associated with psychotic illness: A 4 year longitudinal follow-up study
(2017-02-20)Introduction: In general, individuals who experience a first-episode of psychosis (FEP) display deficits on a wide range of neuropsychological tasks compared to psychiatrically healthy individuals (Bora et al., 2014). ... -
Investigation of pathogenic vibrio in Irish aquaculture
(NUI Galway, 2023-07-31)Vibrio parahaemolyticus, Vibrio vulnificus and Vibrio cholerae are marine pathogens that cause gastroenteritis in humans after the consumption of infected shellfish. Vibrio can cause devastating losses of oysters, shrimps ... -
Investigation of radon prevention and mitigation: from radon measurements to specification for soil depressurisation systems
(NUI Galway, 2020-01-27)Reduction of indoor radon concentration in buildings is considered to be an important public health issue, since radon was recognised as the leading cause of lung cancer after tobacco smoking by the World Health Organisation. ... -
An investigation of reading abilities and the impact of programmed instruction on reading outcomes in children with autism specrtum disorder
(NUI Galway, 2018-05-11)This thesis investigates reading abilities and programmed instruction, i.e., instruction that is scripted and sequenced, with explicit learning goals, based on the principles of Applied Behaviour Analysis, in children with ... -
Investigation of sexual dimorphism in an animal model of neuropathic pain: role of the endocannabinoid system
(NUI Galway, 2023-05-15)Although the presence of sexual dimorphism in the symptomatology of neuropathic pain is well-established, the neurobiology underlying sex differences in pain processing and modulation remains unclear. Gonadal hormones ... -
Investigation of T cell receptor and immunoglobulin repertoire through next generation sequencing data
(2017-08-08)The diversity of the immunological repertoire has long been a subject of research focus, providing important insights into the adaptive immune system. Rapid developments in next generation sequencing technologies ... -
Investigation of the central serotonergic system in the olfactory bulbectomized rat model of depression
(2017-11-10)Depression is a devastating heterogeneous disease that has a high lifetime prevalence. Despite over 50 years of research, the aetiology of depression is still largely undetermined but the improper functioning of the central ... -
An investigation of the contribution of centrosomal genes to schizophrenia and cognitive function
(NUI Galway, 2020-03-11)The centrosome is the key microtubule organising centre of animal somatic cells. Centrosomes play a crucial role in brain development, influencing cell shape, polarity, motility, and division. The older of the two barrel-shaped ... -
An investigation of the effects of thermal and nonthermal processing methods on Polyacetylenes from Apiaceae
(2012)Polyacetylenes are a group of phytochemicals that have attracted significant interest in recent years due to their range of potential health-promoting bioactivities however, little is known about the effects of food ... -
Investigation of the genetic basis of schizophrenia and cognitive function
(NUI Galway, 2019-01-25)Schizophrenia (SZ) is a chronic psychiatric disorder affecting approximately 1% of the population. Symptoms range from delusional thoughts and hallucinations to anhedonia and social withdrawal. Affected individuals also ... -
An investigation of the genetic contribution to cognitive resilience in healthy ageing
(NUI Galway, 2021-07)Cognitive decline is one of the most feared aspects of ageing leading to major health and social issues. Non-pathological or age-related cognitive decline leads to increased challenges in completing tasks that require ... -
An investigation of the immunometabolic interactions of obesity
(2013-09-04)Human monocytes are classified as classical, intermediate and non-classical according to their surface expression of CD14 and CD16. They also represent precursors to atherogenic foam cells and macrophages in metabolically ... -
Investigation of the mechanisms of repair following Ventilator Induced Lung Injury and the potential for Mesenchymal Stem Cells to enhance the repair process
(2012-02-10)Introduction: ARDS is a syndrome of acute respiratory failure that presents with progressive arterial hypoxemia, dyspnea, and a marked increase in the work of breathing. Virtually all patients with ARDS receive mechanical ... -
An investigation of the relationship between international law, international politics and the state using Syria as a case study
(NUI Galway, 2018-11-20)The thesis investigates the relationship between international law, international politics and the state using Syria as a case study. Syria was chosen because it has historically been the site of regional and international ...