Browsing University of Galway Theses (PhD Theses) by Title
Now showing items 1002-1021 of 2242
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Hypertextualized Virtual Environments: Dual-Mode User Interface Design
(2011-06-03)This thesis develops a novel strategy for accessing Hypertextualized Virtual Environments (HiVEs), integrated information spaces where symbolic (hypertext) and visual (3D graphics) data are simultaneously available and ... -
Hypoxia activates the PTHrP – Zfp521 – MEF2C pathway to attenuate hypertrophy in mesenchymal stem cell derived cartilage
(2016-04-22)The treatment of cartilage defects remains an unmet medical need as the current treatment options are currently sub-optimal as the most common treatment options; microfracture and autologous chondrocyte implantation (ACI) ... -
“I have loads of cool ideas…” A study of the nature of young children’s autonomous participation in a strategic policy development process
(NUI Galway, 2021-12-21)Children’s participation is increasingly recognised as informing the development of policies and strategies that are concerned with service provision for children and families. Creating space for children to express their ... -
'I'm not going to be able to leave'; The impact of belonging to the Irish farming community on university students' life experiences and transitions to adulthood
(2014-02-10)Despite extensive research into family farming culture little attention has been paid to young people raised in this community who do not become full-time farmers. This thesis explores the childhood experiences of university ... -
I-Ulysses: poetry in motion. An educational virtual reality guide to the unfolding events of the ‘Wandering Rocks’ chapter of Joyce’s Ulysses.
(2016-01-29)A spatial and temporal virtual reality experience, guiding the user through the unfolding events of the ‘Wandering Rocks’ chapter of James Joyce’s Ulysses. This is an educational tool intended to help the user understand ... -
Identification and analysis of polymorphisms in miRNA genes and associated targets in Bos taurus and Bos primigenius for genomic selection in cattle
(2017-02-21)Cattle production is of high economic importance to agriculture in Ireland. For more than a decade, significant effort focused on the improvement of the selection of economically important traits in beef and dairy breeds. ... -
Identification and characterisation of germline variants in an Irish cohort with breast cancer
(NUI Galway, 2020-02-10)Breast cancer is the most common female malignancy worldwide, and the second most common cause of cancer-related deaths in women. Twin studies estimate that up to one third of breast cancers are the result of hereditary ... -
Identification and characterisation of novel glycan-binding bacterial adhesins encoded by the human gut microbial metagenome
(2017-03-24)Although there have been an increasing number of scientific publications describing the adherence of gut bacteria to components of the human intestinal mucosa, very little is known about the surface molecules mediating ... -
Identification of bioactive natural products after screening Irish marine bio-resources
(2016-10-21)According to the “Real Map of Ireland” published by Marine Institute, Ireland, the Nation marine territory has ten times more area than its land mass. Despite the well-studied and reported biodiversity present in Irish ... -
Identification of compounds that may be repurposed for the treatment of triple negative breast cancer
(2012-11-21)Triple negative breast cancers (TNBC), lack the estrogen and progesterone receptors as well as the HER2 receptor. Currently, there is no selective therapy for the treatment of TNBC and current treatment regimens rely on a ... -
Identification of decisive molecular interactions regulating resistance to apoptosis in tumour cells
(14-07-04)TRAIL is a member of the TNF family of cytokines which can selectively induce apoptosis in cancerous cells. For this reason recombinant TRAIL is being considered for the treatment of cancer. During their development cancer ... -
Identification of growth limiting factors in Synechocystis sp. PCC 6803
(2018-02-15)In this study we showed that Synechocystis sp. PCC 6803 can achieve fast division rates using urea, a low-cost nitrogen source that does not require energy for uptake and hydrolysis, and releases CO2 into to the cell during ... -
Identification of IRS4 and TOP2A as novel CDC7 kinase interacting proteins
(2016-02-08)CDC7 is an essential serine/threonine kinase required for the initiation of DNA replication in eukaryotic cells, through phosphorylating the MCM helicase complex. Formation of an active kinase requires the binding to ... -
Identification of novel drug combinations for haematological malignancies
(2015-01-29)TNF-related apoptosis ligand (TRAIL) is a tumour selective cytokine with potential anti-cancer activity which is currently in clinical trials. Haematological malignancies along with several other cancers have showed varied ... -
Identification of novel factors that promote trinucleotide repeat instability
(2013-09-23)Trinucleotide repeat (TNR) expansions are the genetic cause of several inherited neurological diseases. Factors that affect the propensity of TNRs to expand include the characteristics of the TNR DNA, the chromatin ... -
Identification of plant-specific components of the Polycomb Group pathway and their roles in the regulation of Arabidopsis thaliana development
(NUI Galway, 2019-09-30)The knowledge about Arabidopsis thaliana developmental life cycle is deep in broad strokes. Nevertheless, the mechanisms that fine tune these phase transitions are still poorly described. One of these mechanisms is the ... -
Identification of prognostic targets in breast cancer using immunohistochemical and in situ hybridisation methodologies
(2011-12-16)Advances in our understanding of the molecular mechanisms underlying breast cancer are leading to improvements in its management. Many of the recent gene-based signatures developed for breast cancer have highlighted the ... -
Identifying novel drug therapies for acute myeloid leukaemia by targeting the interactions between leukaemia cells and bone marrow microenvironment
(NUI Galway, 2019-10-25)Acute myeloid leukaemia (AML) is a malignancy caused by a block in differentiation in which aberrant leukemic stem cells drive the production of undifferentiated or partially differentiated leukemic blast cell clones. ... -
Identifying novel strategies to re-engage the apoptotic pathway for the treatment of cancer
(2014-09-30)In chapter two we demonstrate that in non-transformed cells multiple signalling pathways control TRAIL resistance and they act in a redundant manner. This is contrary, however, to the resistance mechanisms found in tumour ... -
Identifying, annotating, and filtering arguments and opinions in open collaboration systems
(2013-09-13)The World Wide Web enables large-scale collaboration, even between groups of individuals previously unknown to one another. These collaborations produce tangible outputs, such as encyclopedias (Wikipedia), electronic books ...