Browsing University of Galway Theses (PhD Theses) by Author "http://dx.doi.org/10.13039/501100002081"
Now showing items 1-20 of 155
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Ablation of FAP+ stromal cells impairs endogenous revascularization during hind limb ischemia
Chao, Joshua (NUI Galway, 2020-05-08)Stromal cells have long been studied for their putative role in maintaining tissue homeostasis, driving tissue remodeling processes during injury, and modulating inflammation by synergizing with immune cells. Studying ... -
After the end of history: Utopia, cities, and the populist imagination
Bierema, Sebastiaan Broeils (NUI Galway, 2023-06-14)Following the electoral success of populist movements in Europe and the Americas throughout the 2010s, liberal democracy is widely believed to be in crisis—a stark contrast to its jubilant victory over alternative ... -
Analysis of the mechanical performance of a biodegradable magnesium stent in a remodelling artery
Boland, Enda L. (NUI Galway, 2018-09-28)Coronary stents made from degradable biomaterials such as magnesium alloy are an emerging technology in the treatment of coronary artery disease. Biodegradable stents provide mechanical support to the artery during the ... -
Anisotropy resolved multidimensional emission spectroscopy (ARMES) for the analysis and resolution of insulin oligomer emission
Casamayou-Boucau, Yannick (NUI Galway, 2018-11-14)Protein aggregation is one of the biggest challenges affecting the manufacture and safe use of biopharmaceuticals. Despite efforts made to enhance protein stability [1], aggregation still remains a critical factor in ... -
Application of CRISPR/Cas9 gene editing to target Neuronal Interleukin-16 a novel protein involved in osteoarthritis progression
Dooley, Claire (NUI Galway, 2022-09-07)Osteoarthritis (OA) is a debilitating joint disease affecting an increasing proportion of the elderly population worldwide annually. Current treatments for the disease are symptomatic with management of pain and side effects ... -
Applying machine learning towards automating resource management in cloud computing environments
Shaw, Rachael (NUI Galway, 2021-01-28)Over the last number of years there has been high acceleration and widespread adoption of cloud based services by many different industries to improve the scalability and reliability of their services while also reducing ... -
Bamboozled! Systematic studies of the Keratoisididae (Octocorallia: Scleralcyonacea)
Morrissey, Declan (NUI Galway, 2023-11-15)Deep-sea corals are globally distributed and form a three-dimensional habitat on the benthos which hosts a diverse invertebrate community. Despite this importance, a global lack of taxonomic expertise and low resolution ... -
Between the queer and the normative: Unorthodox representations of gender, power and desire in W. B. Yeats’s and Gabriele D’Annunzio’s Drama
Balázs, Zsuzsanna (NUI Galway, 2021-10-08)This doctoral thesis re-examines W. B. Yeats’s and Gabriele D’Annunzio’s drama through the lens of queer theory offering the novel contention that due to their involvement in queer and feminist subcultures, their plays ... -
Biofortification for better nutrition: developing and delivering crops with more impact
Hummel, Marijke (NUI Galway, 2020-05-06)Background: Globally, around three billion people have inadequate diets and are often malnourished. Biofortification, a nutrition-sensitive approach that aims to increase the nutritional density of staple crops, has great ... -
Building the evidence base for the development and implementation of an Irish national digital Type 2 Diabetes prevention programme
Van Rhoon, Luke (NUI Galway, 2022-12-09)Background: Type 2 Diabetes Mellitus (T2DM) represents a major public health concern. Over one million annual deaths worldwide are attributed to the disease, making it the ninth leading cause of mortality. In Ireland, the ... -
Carbon fibre reinforced PEEK laminated as a material for orthopaedic devices: An experimental and computational investigation
Gallagher, Elizabeth Anne (NUI Galway, 2018-11-27)The overall objective of this thesis is to investigate carbon fibre reinforced poly-ether-ether-ketone (PEEK) laminates as a material for fracture fixation devices through a combination of experimental testing and computational ... -
Changing diet and physical activity behaviour in type 2 diabetes
Cradock, Kevin (NUI Galway, 2022-03-14)The aim of this thesis was to design an artefact to support diet and physical activity behaviour change in people with type 2 diabetes. The first step was to identify behaviour change techniques (BCTs) in diet and physical ... -
Characterising bases of pure difference ideals
Burke, Isaac Zebulun (NUI Galway, 2020-09-10)In this thesis, we study the basis sets of pure difference ideals, that is, ideals that are generated by differences of monic monomials. We examine the action of the hyperoctahedral group on the defining ideal of the Segre ... -
Characterization of a novel zebrafish model of arrhythmogenic right ventricular cardiomyopathy
Lynskey, Tracy (NUI Galway, 2018-12-14)Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) is a congenital heart disorder characterized by replacement of the ventricular myocardium with fibrofatty tissue. The majority of cases are due to mutations in genes ... -
Cognitive functioning in schizophrenia: Characterising the effects of common genetic variation, brain structure, inflammation, and early life adversity
Corley, Emma (NUI Galway, 2024-03-08)Schizophrenia is a complex, highly polygenic neuropsychiatric disorder. Individuals with schizophrenia experience neurocognitive and social cognitive deficits that can impact their ability to work, live independently, ... -
A computational and experimental investigation of the in-vivo biomechanics of the human aorta
Concannon, Jamie (NUI Galway, 2020-07-06)The overall objective of this thesis is to provide a new understanding of the degree of biomechanical heterogeneity that exists along the human aorta, against the backdrop of clinical literature reporting that patient ... -
A computational investigation of the long-term performance of bioabsorbable magnesium-based implants in orthopaedic fracture applications
Quinn, Conall (NUI Galway, 2023-06-20)Current orthopaedic fixation devices made from stainless steel and titanium can lead to a range of long-term complications that include bone reabsorption due to stress shielding, implant loosening and/or infection. ... -
Computational modelling framework for predicting the evolution of biodegradable polymers during degradation
Hill, Aoife (NUI Galway, 2022-11-28)Biodegradable polymers are attractive alternatives for many permanent implants, potentially reducing long term risks. Designing optimal devices for their intended purpose, however, is costly and time consuming, with small ... -
Computing invariants of knotted manifolds
Killeen, Kelvin (NUI Galway, 2022-09-13)In this thesis, we develop algorithms in computational topology for working with regular CW-complexes and calculating associated homological invariants. We adapt the classical notion of broken surface diagrams for describing ... -
Conceptualising domestic violence against women: Between gender-based universal human rights duty and gender-blind national responses
Bukauskaite, Jurgita (NUI Galway, 2021-03-22)Despite widespread international acknowledgement of domestic violence against women and a plethora of governmental commitments to eliminate it, the issue remains as prevalent today as it was at the beginning of the domestic ...