Browsing University of Galway Theses by Subject "School of Natural Sciences"
Now showing items 1-20 of 22
-
Analysis of the DNA damage response in model systems
(2014-07-24)The integrity of our DNA is constantly threatened by endogenous and exogenous sources of damage. In the absence of sufficient repair mechanisms, this damage can lead to mutations, potentially resulting in the development ... -
The anomerisation of glycosidic linkages
(2014-04-07)This thesis deals with the anomerisation of glycosidic linkages using TiCl4 and SnCl4. Methods involving the Lewis acid induced anomerisations of glycosides have been published over the past decade, however this methodology ... -
Ctrl-atl-delete: Re-thinking the mechanisms of biofilm formation by staphylococci
(2015-04-07)Biofilm formation by staphylococci on implanted medical devices represents a major virulence mechanism and a serious threat to hospital patients. Staphylococcus aureus strains including, methicillin-resistant S. aureus ... -
Development of a targeting mechanism for regeneration of the intervertebral disc
(2014-11-24)Degeneration of the intervertebral discs (IVD) is a leading cause of neck and low back pain. While its aetiology is poorly understood, it is known to begin in the central nucleus pulposus region, leading to degradation of ... -
An evaluation of the applicability of microarrays for monitoring toxic algae in irish coastal waters
(2014-03-14)Monitoring of toxic phytoplankton is traditionally carried out by light and electron microscopy. However, the use of molecular methods for identification and quantification are now becoming more prevalent. Existing ... -
Exploring synthetic strategies towards novel magnetic materials - a structural, magnetic and spectroscopic study
(2015-09-03)This thesis reports the exploration of various synthetic strategies towards the synthesis of novel magnetic materials, which were studied both structurally and spectroscopically. An outline of results chapters is given ... -
Functional Analysis of Vertebrate Msl2
(2014-02-12)hMSL2 (Male Specific Lethal 2, human) is a RING finger protein with E3 ubiquitin ligase activity. Although it has been shown to target histone H2B at lysine 34 and p53 at lysine 351, suggesting roles in transcription ... -
Genetic and biotechnological development of the pennate marine diatom Phaeodactylum tricornutum for high-value bioproducts and carbon bio-mitigation.
(2014-04-25)Conflicting demands of food over fuel and the mushrooming need for feed and fibre are serious challenges for humankind at a time when we also need to address climate change challenges. Global demands for land based commodities ... -
Genome dosage and parent of origin effects in a ploidy series of Arabidopsis thaliana
(2013-11-11)Polyploidy, the presence of more than two sets of chromosomes in an organism, plays major roles in plant evolution, development and function. Understanding the effects of polyploidization at the phenotypic and molecular ... -
Habitats plants and invertebrates as tools for rapid identification of high nature value farmland
(2015-02-13)The EU, in recognition that low intensity farming plays an important role in conserving biodiversity, is committed to identifying and protecting High Nature Value (HNV) farming. Most methods used to date to delineate areas ... -
Hydrolysis, methanogenesis and bioprocess performance during low-temperature anaerobic digestion of dilute wastewater
(2015-04-28)Anaerobic digestion (AD) technologies represent sustainable and appropriate systems for the treatment of organic wastewaters. Lettinga et al (1987) stated, "A satisfactory application to raw domestic sewage would represent ... -
Identification of novel drug combinations for haematological malignancies
(2015-01-29)TNF-related apoptosis ligand (TRAIL) is a tumour selective cytokine with potential anti-cancer activity which is currently in clinical trials. Haematological malignancies along with several other cancers have showed varied ... -
Infilling wetlands with construction and demolition (C&D) waste: Influence on land use, plant/dipteran communities and metal contamination
(2015-01-28)Construction and demolition (C&D) waste, comprised of sand, stone, concrete, bitumen and other wastes from building sites, is one of the largest fractions of waste produced internationally. It frequently ends up being used ... -
An Integrated Approach to Characterising the Hydrogeology of the Tynagh Mine Catchment, County Galway, Ireland
(2014-01-08)The first major Pb-Zn mine in Ireland, located near the village of Tynagh, in east County Galway operated from the early 1960s until the early 1980s producing almost eight million tonnes of ore from surface and underground ... -
The kinesin KIF18B interacts with 53BP1 and is required for efficient double strand break repair
(2015-11-19)Genetic changes can lead to detrimental genomic instability, mutagenesis, oncogenesis and premature aging. The DNA damage response (DDR) is responsible for safeguarding the genome from such harmful alterations. 53BP1 ... -
Nucleolar reorganisation promotes repair of rDNA double strand breaks by homologous recombination throughout the cell cycle.
(2013-12-16)The nucleolus is the largest functional domain within the nucleus and is the site of ribosome biogenesis. It has a distinct structure and houses ribosomal RNA gene (rDNA) transcription, pre-ribosomal RNA (pre-rRNA) processing, ... -
The primary cilium as a regulator of cellular senescence in human fibroblasts
(2014-02-11)Somatic cells senesce in culture after a finite number of divisions, indefinitely arresting their proliferation. Among the major causes of senescence is persistent DNA damage signalling. DNA damage and senescence increase ... -
Reproductive Genetics and Epigenetics of F1 hybrid triploids of Arabidopsis thaliana L.
(2011-12-14)Polyploidy, the occurrence of more than two complete sets of chromosomes in a single nucleus, is an important process contributing to eukaryotic evolution. Polyploidy is also a widespread speciation mechanism and is common ... -
The RNA-associated splicing-factor p54nrb regulates survival of human cells following UV irradiation
(2013-04)UV radiation causes several forms of DNA damage; the most prominent of these are cyclobutane pyrimidine dimers (CPDs) and 6-4 pyrimidine-photoproducts (6-4 PPs). Nucleotide excision repair (NER) is a repair process that ... -
The roles of centrins/caltractins at the centrosome and in genome maintenance
(2012-06-21)The principal microtubule-organising centre in animal cells, the centrosome, contains centrin, a small, highly-conserved calcium-binding protein that can be found throughout eukaryotes. Several centrin isoforms exist and ...