Browsing NUI Galway Theses by Subject "DNA replication"
Now showing items 1-3 of 3
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DNA mediated chromatin pull-down: a novel method for the study of chromatin replication
(2012-04-27)Chromatin replication involves duplicating DNA while maintaining epigenetic information. These processes are critical for genome stability and for preserving cell-type identity. To investigate how these processes are ... -
Identification of IRS4 and TOP2A as novel CDC7 kinase interacting proteins
(2016-02-08)CDC7 is an essential serine/threonine kinase required for the initiation of DNA replication in eukaryotic cells, through phosphorylating the MCM helicase complex. Formation of an active kinase requires the binding to ... -
USP9X controls DNA replication fork stability and the replication stress checkpoint through Claspin
(2016-02-05)Cells possess checkpoint pathways which are important for maintaining genome stability and preventing cancer. These signalling pathways include the ATR and CHK1 kinases which are activated in response to DNA damage or ...